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IMC512 Renal

Flashcards 1: Renal Blood Flow

QuestionAnswerAdditional info
What is the effect of ACE inhibitors on the diameter of the efferent arteriole? Efferent dilation as the constrictive effect of AngII is blocked ACE inhibitors are contraindicated in dehydrated individuals because they could cause a dangerous drop in GFR
What is the effect of prostaglandins on renal blood flow? RBF rises. Prostaglandins are afferent dilators. NSAIDs inhibit prostaglandin synthesis and are contraindicated in renal ischemia to preserve renal O2 supply.
What is the effect of systemic (high dose) AngII on GFR? GFR falls Afferent and efferent constriction lowers RBF and GFR.
What is the effect of efferent arteriolar constriction on RBF and GFR? RBF falls, GFR rises Despite the overall increase in arteriolar resistance, the hydrostatic pressure in the glomerular capillary bed is raised by the efferent constriction.
What is the name of the salt sensing area of the nephron between the TAL and distal tubule? The macula densa
In tubuloglomerular feedback, what is the effect of increased salt delivery to the macula densa on GFR? GFR falls The macula densa switches off local AngII production lowering efferent resistance and reducing salt filtration
What is the location of renin secretion? Cells in the afferent arteriole wall
What are the two effects of sympathetic innervation on the afferent arteriole with low ECFV? Vasoconstriction and renin release. A fall in RBF and GFR preserves ECFV.
Created by: IMC512
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