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Hematology OOF
| Question | Answer |
|---|---|
| Which abnormal hemoglobin may be formed in alpha thalassemia? | Hb Bart's |
| Hemoglobin Lepore | abnormal hemoglobin due to the fusion of delta and beta chains resulting from a fusion gene formed by unequal crossing over. |
| Hemoglobin E | hemoglobinopathy resulting from a single amino acid substitution on the beta chain. In hemoglobin E, lysine substitutes for glutamic acid on the 26th position of the beta chain. |
| Hemoglobin S | hemoglobinopathy resulting from a single amino acid substitution on the beta chain. In hemoglobin S, valine substitutes for glutamic acid on the sixth position of the beta chain. |
| primary myelofibrosis | - bone marrow is filled with fibrous tissue - extramedullary hematopoiesis - Teardrop RBCs - Nucleated RBCs - Immature myeloid cells in the peripheral blood |
| Polycythemia vera | - general increase in red blood cells |
| infectious mononucleosis | - an infection caused by the Epstein-Barr virus (EBV) - fever, a sore throat, and enlarged lymph nodes - Reactive lymphocytes |
| nonmegaloblastic anemia | liver disease, alcoholism, reticulocytosis, metabolic disorders, drugs (5-FU, AZT, hydroxyurea) presence of round macrocytes |
| megaloblastic anemia | a blood disorder characterized by anemia in which oval macrocytes hypersegmented neutrophil |
| Which hemoglobin migrates alone in cellulose acetate at an alkaline pH? | HgbA and HgbF |
| Which hemoglobin migrates together in cellulose acetate at an alkaline pH? | - HgbS, G, and D migrate to the same position - HgbC migrates with A2 and E |
| What causes the hemolysis associated with malarial infections? | Multiplication of merozoites within erythrocytes |
| hemoglobin F concentration of 100% may be seen in which beta thalassemia? | Delta-beta thalassemia major (dß0/dß0) |
| Hemoglobin H bodies can directly alter which of the following? | Integrity of the RBC membrane |
| Which of the following methods for long-term diabetic monitoring is recommended for patients with sickle cell anemia? | Fructosamine |
| FAB system requires ______% of non-erythroid blasts to be present in the bone marrow/peripheral blood for the classification of acute leukemia. | 30% |
| the WHO system requires the presence of ________% non-erythroid blasts for the Classification of acute leukemia. | 20% |
| The MOST accurate observation about osmotic pressure is that it is: | Proportional to concentration of solute particles |
| Newborns who will develop Hemoglobin H disease may demonstrate up to 30% of which type of hemoglobin? | Bart's |
| Lepore | autosomal recessive genetic mutation leading to crosslinking of two alpha and two delta-beta chains not seen in hemoglobin H disease. |
| Bart's | diagnostic hemoglobin in neonates for alpha thalassemia |
| microangiopathic anemia. | Schistocytes, keratocytes, and teardrop cells |
| abetalipoproteinemia | Acanthocytes |
| thalassemia findings | codocytes (target) |
| G6PD deficiency | bite cells and Heinz bodies |
| Acute Myelocytic Leukemia | Cancer of the myeloid line of blood cells - rapid growth of abnormal white blood cells - interfere with the production of ntormal blood cells - positive Myeloperoxidase, Sudan Black B, and Chloroacetate Esterase. - target the myelocytic blast cells. |
| Acute Monocytic Leukemia | FAB M5 Nonspecific Esterase positive (+) CD 14 , CD 64 positive (+) |
| Cooley's anemia | beta thalassemia major which is a microcytic, hypochromic anemia. |
| Iron deficiency anemia | microcytic, hypochromic anemia. |
| Pernicious anemia | lack of mature erythrocytes caused by inability to absorb vitamin B12 into the bloodstream megaloblastic anemia associated with macrocytic, normochromic red blood cells. |
| small club-shaped, "drumstick" nuclear appendage attached to one lobe of a neutrophil (marked by the blue arrow in the image) may be found in: | Normal female |
| causes for high eosinophil counts | - Infections of parasitic helminths - Allergic reactions - Chronic Myelogenous Leukemia |
| Forward scatter | is directly proportional to particle or cell size. |
| Side scatter | is proportional to the surface and cytoplasmic complexity. Cytoplasmic granules and vacuoles increase side scatter. |
| Hydrops Fetalis | Heart failure and generalized edema in the fetus secondary to severe anemia resulting from destruction of erythrocytes. Alpha thalassemia major all four alpha chain gene loci are deleted or non-functional. |
| Heinz bodies | Intracellular inclusions seen in thalassemia, G6PD deficiency, and postsplenectomy denatured hemoglobin. |
| Cabot rings | Mitotic spindle Remnants of microtubules |
| Which of the following is the cause of thrombotic thrombocytopenic purpura (TTP)? | ADAMTS13 deficiency |
| Which of the following gene translocations is associated with Acute Promyelocytic Leukemia (APL)? | t(15;17) |
| Multiple myeloma | malignant neoplasm of bone marrow - rouleux formation due to the increased immunoglobulins present. |
| Aplastic anemia | failure of blood cell production in the bone marrow infection, are on medication |
| cell markers are useful in the diagnosis of paroxysmal nocturnal hemoglobinuria (PNH)? | CD55 and CD59 |
| hereditary hemochromatosis (HH) | inherited genetic defect that causes people to absorb too much iron >45% transferrin |
| Alder Reilly Anomaly | inability to degrade mucopolysaccharides results in an accumulation of the lipid in the cells leading to a heavily granulated appearance. |
| Niemann-Pick Disease. | Sphingomyelinase accumulation |
| Gaucher Disease | Beta-glucocerebrosidase |
| enzyme found within the granules of normal segmented neutrophils | Myeloperoxidase |
| Alpha thalassemia intermedia | Hemoglobin H disease microcytic, hypochromic anemia. |
| Which of the following is an FDA-approved therapeutic agent for treating sickle cell patients? | Butyric acid |
| May-Hegglin anomaly | Dohle body-like inclusions (large, blue-staining cytoplasmic inclusions), as well as bizarre/giant platelets. |
| abetalipoproteinemia | a rare inherited disorder affecting fat absorption by the intestine and mobilization by the liver. acanthrocyte |
| Vitamin K dependent factors | Factors II, VII, IX, and X, and proteins C, S, and Z |
| Which of the following forms of hemoglobin cannot be detected by routine hemoglobin methods? | Sulfhemoglobin |
Created by:
Casey_Cee
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