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UNIT V- LIPIDS
BIOCHEMISTRY
| Question | Answer |
|---|---|
| 1. Comprise very heterogeneous group of compounds which are insoluble in water but soluble in non-polar organic solvents such us benzene, chloroform, and ether. They are present in all living organisms. The group includes fats, oils, waxes and related com | Lipids |
| 2. Esters of fatty acids with different alcohols. | Simple lipids |
| 3. Esters of fatty acids and alcohols together with some other head groups. | Complex lipids |
| 4. Include the hydrolytic products of the simple and complex lipids. Eg. Fatty acids, cholesterol etc. | Derived lipids |
| 5. These are esters of fatty acids with glycerol. | Fats and oils |
| 6. Esters of fatty acids with high molecular weight monohydric alcohols. | Waxes |
| 7. Lipids containing fatty acid, sphingosine and carbohydrate residues. | Glycolipids |
| 8. Are building block of most lipids, made of long chain organic acids having one polar carboxyl group (head) and a non-polar hydrocarbon chain (tail). | Fatty acids |
| 9. They have two or more double bonds they are called as essential fatty acids because they are required in the body and cannot be synthesized. So they need to be include in the diet. | PUFA (Polyunsaturated fatty acids |
| 10. It is semi essential fatty acid because it can be synthesized from the above two essential fatty acids. | Arachidonic acid |
| 11. These are esters of fatty acids with the alcohol glycerol, which are storage forms of lipids (depot lipids). Also called as triacylglycerides. | Triacylglycerols |
| 12. It is the parent compound for the formation of the different glycerophospholipids. | Phosphatidate |
| 13. Contain as head group phosphocholine or hosphoethanolamine. | Sphingomyelins |
| 14. These are glycolipids which have no phosphate group but neutral head group and contain one or two sugar groups usually glucose or Galactose. | Cerebrosides |
| 15. These are glycolipids most of which are complex containing oligomers of sugars on head groups. | Gangliosides |
| 16. Are complex fat-soluble molecules, which are present in the plasma lipoproteins and outer cell membrane. | Steroids |
| 17. It is one of the important non fatty acid lipids that is grouped with steroids. | Cholesterol |
| 18. The three compounds that are collectively known as ketone bodies. | acetoacetate, βhydroxybutyrate, and acetone |
| 19. Join the electron transport chain as high energy electron carriers. | FADH2 and NADH +H+ |
| 20. Requires two additional enzymes called isomerase and reductase. | oxidation of unsaturated fatty acids |
| 21. Are the normal substrates for respiration and important sources of energy. | Aceto acetate and β-hydroxy butyrate |
| 22. The main sources of NADPH for fatty acid synthesis | pentose shunt |
| 23. It is the deposition of lipids in the connective tissues of intima of arteries. It causes obstruction to blood flow, leading coronary heart disease, stroke, myocardial infarction etc. | atherosclerosis |
| 24. Absence of bile salts precipitate cholesterol as gall stones. | Cholelithiasis |
| 25. Sphingomyelin accumulates in brain, liver and spleen .The condition is due to deficiency of sphingomyelinase .Patient suffers from mental retardation and early death. What type of disease? | Nieman-pick disease |
| 26. Glucocerebroside accumulates in liver, spleen, brain and bone marrow, due to the deficiency of glucocerebrosidase. Patient suffers from mental retardation. What type of disease? | Gaucher’s disease |
| 27. Hexosaminidase is absent as a result gangliosides accumulate in brain, spleen and retina. Patient suffers from demyelination. Cerebral degeneration, mental retardation and early death. What type of disease? | Tay-Sachs disease |
| 28. These are derived from intestinal absorption of triacylglycerols and other lipids and have a very short lifespan. (Chylomicrons) | Chylomicrons |
| 29. These are synthesized in the liver and used to transport triacylglycerols from the liver to extrahepatic tissues. | VLDL (very low density lipoproteins) |
| 30. These are produced from the final stage in the catabolism of VLDL. They transport cholesterol synthesized in the liver to peripheral tissues. | LDL (Low density lipoproteins) |
| 31. It has the highest density in this group since it contains more protein and cholesterol than triacylglycerols. It transports excess cholesterol from peripheral tissues to the liver for degradation and removal. | HDL (High Density Lipoproteins) |
| 32. Are important biological structures, which are indispensable for life. It gives cells their individuality by separating them from their surrounding and they are highly selective and semi permeable containing specific gates, pumps, and channels. | Membranes |
| 33. Are found submerged in the sea of the lipid bilayers (intrinsic proteins) or loosely bound (extrinsic proteins). | Proteins |