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CCTM
Current advances in Transfusion 2020
Question | Answer |
---|---|
What are the top 2 infectious risk to blood supply in USA? | 1. bacterial contamination of platelets 2. babesiosis |
Describe the options for mitigating the risk of bacterial contamination of platelets according to FDA guidance issued in 2019 | 1. pathogen reduction 2. large volume primary culture 3. secondary culture. 4. point-of-issue testing(VERAX) |
What was the FDA 2019 recommendation for reducing transfusion transmitted babesiosis? | testing in endemic states (14 plus DC) or pathogen reduction |
What is the overall viral transmission rate from transfusions in USA | less than 1 in 1,000,000 |
What is the deferral period for diagnosis of, or a positive test for babesisosis? | 2 years |
What is the male sex with male deferral period in 2020? | 3 months |
What did the CHILL study demonstrate? | Iron deficiency is a risk for donors 16-18 years old at any donation interval |
How much iron in mg is in a unit of donated whole blood? | 250mg |
What are the minimum hemoglobin values for blood donors? | 12.5 g/dL for females; 13 gm/dL for males |
What is the inter-donation interval for whole blood collections? | 56 days (8 weeks) |
Which can interfere with pre-transfusion testing? A. anti-CD38 B. anti-CD-47 C. both D. neither | C |
Which drug's interference can be resolved with DTT pretreatment in pre-transfusion testing? A. anti-CD38 B. anti-CD-47 C. both D. neither | A |
How often are RBC genotype and RBC serology in conflict? | In chronically transfused patients, 77% discordance across Rh,Kidd,Duffy, Kell. For instance RhD+ SCD patients are at a 6% risk of forming an anti-D. (partial D); also true for C,c,e (21%). (Mosaics) |
Describe treatment options for CAD |