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Current advances in Transfusion 2020

QuestionAnswer
What are the top 2 infectious risk to blood supply in USA? 1. bacterial contamination of platelets 2. babesiosis
Describe the options for mitigating the risk of bacterial contamination of platelets according to FDA guidance issued in 2019 1. pathogen reduction 2. large volume primary culture 3. secondary culture. 4. point-of-issue testing(VERAX)
What was the FDA 2019 recommendation for reducing transfusion transmitted babesiosis? testing in endemic states (14 plus DC) or pathogen reduction
What is the overall viral transmission rate from transfusions in USA less than 1 in 1,000,000
What is the deferral period for diagnosis of, or a positive test for babesisosis? 2 years
What is the male sex with male deferral period in 2020? 3 months
What did the CHILL study demonstrate? Iron deficiency is a risk for donors 16-18 years old at any donation interval
How much iron in mg is in a unit of donated whole blood? 250mg
What are the minimum hemoglobin values for blood donors? 12.5 g/dL for females; 13 gm/dL for males
What is the inter-donation interval for whole blood collections? 56 days (8 weeks)
Which can interfere with pre-transfusion testing? A. anti-CD38 B. anti-CD-47 C. both D. neither C
Which drug's interference can be resolved with DTT pretreatment in pre-transfusion testing? A. anti-CD38 B. anti-CD-47 C. both D. neither A
How often are RBC genotype and RBC serology in conflict? In chronically transfused patients, 77% discordance across Rh,Kidd,Duffy, Kell. For instance RhD+ SCD patients are at a 6% risk of forming an anti-D. (partial D); also true for C,c,e (21%). (Mosaics)
Describe treatment options for CAD
Created by: jfshikle
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