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FDA circular 3

blood and blood products

QuestionAnswer
What is the count of an apheresis granulocyte product? 1x10(10)
Storage time and temperature for granulocytes 24 hours and 20-24 degrees C
Indications for granulocytes bacterial or fungal infection not responding to standard therapy, ANC <500, marrow must have chance of recovering
Requirements for granulocyte transfusion once patient is properly selected and product is collected Must be ABO compatible. Must be irradiated.
Describe side effects and hazards of granulocyte transfusions FNHTRs, allergic reactions, pulmonary reactions, HLA alloimmunization
describe pathogen reduction combination of UV light and photosensitizers which damages nucleic acids to prevent replication
what products can be pathogen reduced by psoralen? Not RBCs, plasma, platelets (yellow)
Organisms that have shown resistance to pathogen reduction Hep A, Hep E, parvovirus B19, poliovirus, Bacillus cereus spores
What dose of irradiation must be used on the center of the bag if pathogen reduced platelets are given to a BMT patient? None, PR mitigates TA-GVHD
indications for leukoreduced blood products decrease FNHTRs, CMV safe, decrease HLA alloimmunization
Describe mechanism of “hypotensive transfusion reaction” in bedside leukoreduction, these reactions can be observed in patients on ACE inhibitors
Standard dose of irradiation to center of blood bag and corners 2500cGy in center, 1500cGy in corners
groups at risk for TA-GVHD intrauterine transfusions, selected immunocompromised patients, components from blood relatives, HLA matched blood products, granulocytes, BMT, purine analogues
What is the expiry of an RBC unit that has been irradiated? 28 days from irradiation or original expiry, whichever is first
What is the expiry of an platelet unit that has been irradiated? unchanged
What does washing remove from blood products? proteins, additives, glycerol
What is the shelf life of a washed RBC unit? 24 hours
What is the shelf life of a washed platelet unit? 4 hours
How long does it take to wash 12 units of plasma? Silly question. Washing is reserved for cellular products
A mother donates platelets for her baby with a dx of NAIT. How should the product be modified before transfusing? It should be washed to remove anti-PLT ab and irradiated to mitigate risk of TA-GVHD
Indications for washing blood products h/o anaphylactic reaction to transfusion, ex. IgA deficiency, haptoglobin deficiency, C4 deficiency
CMV safe blood product indications pregnant women, low birth weight infants, transplant recipient, immunosuppressed, HIV
Created by: jfshikle
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