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FDA circular 3
blood and blood products
| Question | Answer |
|---|---|
| What is the count of an apheresis granulocyte product? | 1x10(10) |
| Storage time and temperature for granulocytes | 24 hours and 20-24 degrees C |
| Indications for granulocytes | bacterial or fungal infection not responding to standard therapy, ANC <500, marrow must have chance of recovering |
| Requirements for granulocyte transfusion once patient is properly selected and product is collected | Must be ABO compatible. Must be irradiated. |
| Describe side effects and hazards of granulocyte transfusions | FNHTRs, allergic reactions, pulmonary reactions, HLA alloimmunization |
| describe pathogen reduction | combination of UV light and photosensitizers which damages nucleic acids to prevent replication |
| what products can be pathogen reduced by psoralen? | Not RBCs, plasma, platelets (yellow) |
| Organisms that have shown resistance to pathogen reduction | Hep A, Hep E, parvovirus B19, poliovirus, Bacillus cereus spores |
| What dose of irradiation must be used on the center of the bag if pathogen reduced platelets are given to a BMT patient? | None, PR mitigates TA-GVHD |
| indications for leukoreduced blood products | decrease FNHTRs, CMV safe, decrease HLA alloimmunization |
| Describe mechanism of “hypotensive transfusion reaction” | in bedside leukoreduction, these reactions can be observed in patients on ACE inhibitors |
| Standard dose of irradiation to center of blood bag and corners | 2500cGy in center, 1500cGy in corners |
| groups at risk for TA-GVHD | intrauterine transfusions, selected immunocompromised patients, components from blood relatives, HLA matched blood products, granulocytes, BMT, purine analogues |
| What is the expiry of an RBC unit that has been irradiated? | 28 days from irradiation or original expiry, whichever is first |
| What is the expiry of an platelet unit that has been irradiated? | unchanged |
| What does washing remove from blood products? | proteins, additives, glycerol |
| What is the shelf life of a washed RBC unit? | 24 hours |
| What is the shelf life of a washed platelet unit? | 4 hours |
| How long does it take to wash 12 units of plasma? | Silly question. Washing is reserved for cellular products |
| A mother donates platelets for her baby with a dx of NAIT. How should the product be modified before transfusing? | It should be washed to remove anti-PLT ab and irradiated to mitigate risk of TA-GVHD |
| Indications for washing blood products | h/o anaphylactic reaction to transfusion, ex. IgA deficiency, haptoglobin deficiency, C4 deficiency |
| CMV safe blood product indications | pregnant women, low birth weight infants, transplant recipient, immunosuppressed, HIV |
Created by:
jfshikle
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