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MLT Blood Bank
Final Review
| Question | Answer |
|---|---|
| Immunohematology | study of blood group antigens and antibodies |
| Antigen | foreign molecules that bind specifically to an antibody |
| In vivo | reaction within the body |
| In vitro | reaction within an artificial environment |
| Autologous | cells or tissue from self |
| Allogeneic | cells or tissue from a genetically different individual |
| Epitope | single antigenic determinant |
| Extravascular hemolysis | RBC destruction by phagocytes residing in the liver and spleen, usually facilitated by IgG opsonization |
| Valency | number of antigen binding site for any given antibody |
| Primary immune response | immune response induced by first encounter with antigen |
| Secondary immune response | immune response induced after second exposure to antigen (activates the memory cells for a quicker response) |
| Anamnestic response | Secondary immune response |
| Affinity | strength of binding between antibody and epitope of antigen |
| Avidity | overall strength of binding |
| Alloantibodies | antibodies with specificity other than self, stimulated by transfusion or pregnancy |
| Antibody screen | test used to determine the presence of alloantibodies |
| Sensitization | the binding of antibody or complement component to red cell |
| Serum to cell ratio | Ratio of antigen on red cells to antibody in serum/plasma |
| Zeta potential | force of repulsion between red cells |
| Zone of equivalence | antigen and antibody are approximately equal |
| Prozone | excess antibody causing false negative reaction |
| Postzone | excess antigen causing false negative reaction |
| False negative | test result that incorrectly indicates a negative |
| Antigram | Profile of antigen phenotypes for each donor used in the manufacture of commercially supplied screening and panel cells |
| Apheresis | method of blood collection where whole blood is removed from a donor and separated into components, one or more is retained, and the remainder is returned to the donor |
| Autocontrol | Testing a person serum with his or her own red cells to determine whether an autoantibody is present. |
| Clinically significant antibody | Antibody capable of causing decreased survival of transfused cells as in a transfusion reaction. |
Created by:
thierer
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