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MLT Blood Bank

Final Review

Immunohematology study of blood group antigens and antibodies
Antigen foreign molecules that bind specifically to an antibody
In vivo reaction within the body
In vitro reaction within an artificial environment
Autologous cells or tissue from self
Allogeneic cells or tissue from a genetically different individual
Epitope single antigenic determinant
Extravascular hemolysis RBC destruction by phagocytes residing in the liver and spleen, usually facilitated by IgG opsonization
Valency number of antigen binding site for any given antibody
Primary immune response immune response induced by first encounter with antigen
Secondary immune response immune response induced after second exposure to antigen (activates the memory cells for a quicker response)
Anamnestic response Secondary immune response
Affinity strength of binding between antibody and epitope of antigen
Avidity overall strength of binding
Alloantibodies antibodies with specificity other than self, stimulated by transfusion or pregnancy
Antibody screen test used to determine the presence of alloantibodies
Sensitization the binding of antibody or complement component to red cell
Serum to cell ratio Ratio of antigen on red cells to antibody in serum/plasma
Zeta potential force of repulsion between red cells
Zone of equivalence antigen and antibody are approximately equal
Prozone excess antibody causing false negative reaction
Postzone excess antigen causing false negative reaction
False negative test result that incorrectly indicates a negative
Antigram Profile of antigen phenotypes for each donor used in the manufacture of commercially supplied screening and panel cells
Apheresis method of blood collection where whole blood is removed from a donor and separated into components, one or more is retained, and the remainder is returned to the donor
Autocontrol Testing a person serum with his or her own red cells to determine whether an autoantibody is present.
Clinically significant antibody Antibody capable of causing decreased survival of transfused cells as in a transfusion reaction.
Created by: thierer