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MLT-DNA Viruse 2
Virology
Question | Answer |
---|---|
What are the 2 example spp of Hepadnaviridae? | 1.Hepatitis B virus 2.Hepatitis D virus |
What is the genus name of Hepatitis B virus? | Orthohepadnavirus |
What does the envelope of HBV contains ? | Glycoprotein- HBsAg |
HBV genome is ____DNA with _______ in size? | 1.Double strand 2.3.2kbp |
Transcription occurs in host hepatocyte _______, genome replication in host cytoplasm, but inside _________? | 1. nucleus 2. viral nucleocapsid |
During HBV transcription, what are the 4 types of mRNA will be transcriped? | 1.3.5kb 2.2.4kb 3.2.1kb 4.0.7kb |
HBV replication is non cytocidal, but what makes it so damaging to liver cells? | 1.Accumulation of viral antigen ( HBcAg & Pre S1 protein) 2.Immunological action of CD8 Tc lymphocytes, NK cells |
What are the 6 serological markers for the detection of HBV? | 1.HBsAg 2.HBV DNA 3.HBeAg 4.anti HBsAg 5.anti HBe 6.anti HBc |
Whats the way to detect the serological markers? | Enzyme-linked Immunosorbent Assay(EIA) or ELISA |
What are the 3 chemotherapy treatment to HBV infection? | 1.Penciclovir , famciclovir 2.Nalidixic acid 3.Interferons |
Hepatitis D Virus genome is ____RNA with _______ in size? | 1.Single strand 2.1.7kbp |
HDV viral protein coat is composed of _______? | HBsAg |
What is coinfection of HDV and HBV? | infected with HBV & HDV simultaneously |
What is superinfection of HDV? | infected with HBV first, followed by HDV |
What makes HDV so damaging to hepatocytes? | P24 HDAg, it is cytotoxic |
What are the 2 chemotherapy treatment to HDV infection? | 1.interferon 2. interferon + nucleoside analogue |
How to detect HDV? | EIA for anti HDV |
What is a reliable way to demonstrate HDV antigen in hepatocyte nuclei? | Immunohistochemical staining of liver biopsy |