Normal Size Small Size show me how
MLT-DNA Virus I
|What are the 3 sub families of Human Herpesviridae?
|1.Alphaherpesvirinae 2.Betaherpesvirinae 3.Gammaherpesvirinae
|What are the examples of Alphaherpesvirinae and and growth rate?
|Herpes simplex virus 1 and Varicella zoster virus, fast-growing
|What is the example of Betaherpesvirinae?
|Cytomegalovirus, grow slowly
|What is the example of Gammaherpesvirinae?
|Epstein Barr virus, poor replicating
|What is the structure of Herpesviridae? (ppt p.8)
|1.dsDNA 2.Icosahedral capsid 3.Amorphous tegument protein 4.Pleomorphic envelope
|DNA replication & encapsidation of Herpesviridae occur in host ________?
|dsDNA genome replicates by viral ______ polymerase?
|Gene expression by host RNA pol but regulated by _________?
|What are the three proteins involved in immediate early, early and late transcription and translation stages of Herpesviridae?
|1.Immediate early: Alpha proteins 2.Early: Beta protein 3.Late: Gamma protein
|What are the function of alpha proteins?
|As transcription factors
|What are the 2 function of beta proteins?
|1.enzymes for synthesis of nucleotides 2.enzymes for viral DNA replication
|What is the function of gamma proteins?
|structural proteins for virus assembly
|What are the two kinds of viral infection?
|1.Productive infection 2.Latent infection
|What are the 3 examples of production infection?
|1.Cytocidal 2.Intranuclear inclusion 3.Syncytia
|In latent infection, Herpesviridae will be presist in the nuclei of _______ or ________ in the form of _______?
|1. neurons or lymphocytes 2. episome
|At the site of epidermal infection, virus is phagocytosed by ___A_____ & ______B_____; the viral antigen is then presented on dendritic cells & macrophages to ____C_____ T cells?
|A.dendritic cells B.macrophages C.CD4
|Epithelial infection is cleared but some viruses escapes & invade the local sensory neurones, how HSV escape antibody surveillance?
|1.binding of viral gE & gI to Fc receptor of IgG 2.protect HSV against immunological attack
|Viruses are transported to & establish latency in the _______ or _______?
|spinal or cerebral ganglion
|What could reactivate Viruses?
|1.Immunosuppression 2.UV 3.Stress 4.Age
|What would be caused by HSV-1and example?
|Oropharyngeal Herpes, herpes labialis (cold sore)
|What would be caused by HSV-2 and example?
|What can be used to treat HSV?
|How does Acyclovir work?
|1.Act ac analogue of GTP 2.Inhibit viral DNA polymerase
|What are the 2 most universal diseases caused by Varicella zoster virus?
|1.varicella (chicken pox) in child 2.zoster (shingles) in elderly
|What is life threatening Varicella zoster virus spp in adults?
|What would be given to pregnant women who has contacted a varicella case a few days before/ after delivery and to the baby as well?
|ZIG (zoster immune globulin)
|Where would the Epstein Barr virus do replication?
|Inside epithelial cells of nasopharynx & salivary glands
|What is the gene of EBV would be activated to immortalize the infected B cell?
|What would be caused by EBV infection in Cantonese and Eskimos?
|What would be caused by EBV infection in African children?
|What is the mechanism of Burkitt’s lymphoma?
|1.Translocation of c-myc(chr8) to Ig gene(chr14) 2.uncontrolled B cell proliferation & arrest differentiation
|EBV is spread through _______, ________, ________ and ________?
|saliva, respiratory aerosol and utensils
|Cytomegalovirus is a __________ pathogen?
|Human Herpesvirus 8 is associated with the development of _________ in AIDS patients?
|What is the transmission route of Kaposi’s Sarcoma in AIDS patients