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KIN 3600

Lec 25

Composition of the Alveolar air does not have the same composition of gases as the atmospheric air
Why does composition of gases as the atmospheric air not have the same -Inhaled air gets mixed with the dead space air - Inhaled air gets mixed with the air that is already in the lungs -Inhaled air gets 100 % humidified -Humidification of the inhaled air adds 4th gas
PAO2 105 mmHg
PACO2 40 mmHg
PAN2 568 mmHg
PAH2O 47 mmHg
Total pressure 760 mmHg
Gas exchange in the lungs ^ pressure to v Pressure
Exchange of the respiratory gasses between the alveolar air and pulmonary capillary blood result of passive diffusion
PA Partial Alveolar pressure
Pa Partial Pressure
In the lungs venous blood is converted to arterial blood
In the muscles arterial blood is converted to venous blood
Factors determining the diffusion rate of respiratory gases across the respiratory membrane -Difference of partial pressure across the membrane (ΔP) -Thickness of the membrane (T) -Surface area of the active respiratory membrane (A) -Solubility of gasses in water (S) -Square root of the molecular weight (√ MW) -Temperature (T°)
Difference of partial pressure across the membrane (ΔP) - ^pressure difference = faster diffusion -Directly Proportional
Thickness of the membrane (T) -Thicker membrane = Slow diffusion -Thinner membrane = Faster diffusion -Inverse proportional
Surface area of the active respiratory membrane (A) - ^ respiratory membrane SA = ^ faster diffusion - Directly proportional
Solubility of gasses in water (S) - ^Solubility = faster diffusion - Directly Proportional - CO2 ^ higher solubility
Square root of the molecular weight (√ MW) - ^ heavier gas = slower diffusion - Inverse proportional
Temperature (T°) - ^ temp = ^ faster diffusion - Directly Proportional
Diffusion rate is directly proportional ΔP, A, S, T°
Diffusion rate is inversely proportional T, √ MW
O2 transport in blood Dissolved in plasma water 1 %
O2 transport in blood As Oxyhemoglobin in RBC 99 % (1.34 ml O2/g Hb)
Hb increases the O2 carrying capacity of blood by approximately 65 times
Blood Hb concentration men 15%
Blood Hb concentration women 13.5%
Anemia Decreased # of RBC or lower than normal Hb content of each RBC
What does anemia do? Reduction in endurance performance because there is already a small about of O2 supplied so it affects aerobic performance
Does anemia affect sprint performance? may not be affected only acute blood loss Depends on anaerobic E.T. not aerobic
Oxyhemoglobin O2 attached to Hemoglobin (Hb)
Deoxyhemoglobin No O2 attach to Hb
Curve can shift R, why? - Effect of pH (Bohr Effect) - Effect of Temperature - Effect of 2,3 BPG levels in RBC - Effect of Pco2
Myoglobin Dissociation Curve - Binds O2 does not let go – strong - Higher affinity for O2 - In muscle, hemo: RCB - Shift more left on curve (75%)
Deep sea diving affects - Nitrogen narcosis - Oxygen poisoning - Effect on PO2 of plasma water - Gas mixture of diving
Nitrogen narcosis -Pressure so high. They get confused & end up dying -N2 forced into blood and joint cartilage -Causes pain -Bubbles in blood (heart attack)
Oxygen poisoning -Partial pressure ^ -Break DNA
Gas mixture of diving o Tanks 99% He o 1% O2 - non narcotic affect
Created by: rmart11



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