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Hematology

Chronic Leukemias

NameMain Characteristics
Chronic Monocytic Gradual, enlarged, lymph nodes & spleen (also pain) Leukopenia Increased numbers of large mature monocytes w convoluted, indented or irregular nuclei and cytoplasmic pseudopods Moderate decrease in platelets
Chronic Lymphocytic - B Cell Normal bone marrow get infiltrated by excessive production of mature lymphocytes Often asymptomatic w detection at a routine physical Leukocytosis = 30 - 200x10^9/L CD5, CD22, CD24
Chronic Lymphocytic - T Cell Normal bone marrow get infiltrated by excessive production of mature lymphocytes Often asymptomatic w detection at a routine physical Leukocytosis = 30 - 200x10^9/L CD2, CD3, CD8
Prolymphocytic Seen in older men B-cell disease w poor prognosis Large numbers of prolymphocytes with smooth nuclear chromatin & large nuclei
Hairy Cell Predominance of B Lymphs that demonstrate phagocytic characteristics Fine hair like cytoplasmic projections
Multiple Myeloma Hyperproliferation of one type of immunoglobulin Increased number of plasma cells in peripheral blood RBC rouleaux formation & increased sedimentation rate Bence Jones protein in urine (50% of patients)
Waldenstrom’s Primary Macroglobulin Plasma cell proliferative disorder Uncontrolled proliferation of lymphocytes & plasma cells Greater degree of maturation of B Lymphs to Plasma cells Chronic anemia & bleeding episodes IgM Thrombocytopenia cytoplasm that is ragged
Created by: nbechen3