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Hematology

Acute Myelogenous & Lymphocytic Leukemia

NameMain Characteristics
AML Minimal Differentiation - FAB M0 Lack of granules or regular staining reactions Blast demonstrate myeloid differentiation
AML without Maturation - FAB M1 Predominant cell = myeloblasts without maturation <10% of all granulocytic cells show evidence of maturation beyond the myeloblast stage
AML w Maturation - FAB M2 ≥20% blasts with evidence of malturation to more mature neutrophils >10% of cells at differentiated stages of maturation: promyelocyte, myelocyte, and metamyelocyte <20% of marrow cells are monocyte and precursors
AML w t(15;17) - FAB M3 Abnormal promyelocytes - both hyper and hypo granular forms exist
Acute Myelomonocytic Leukemia - FAB M4 ≥20% of blasts are myelocytic ≥20% of blasts are monocytic
Acute Monocytic Leukemia - FAB M5 >20% are monocytic series (often blasts & promonocytes) <20% are myeloblasts & granulocytic If most monocytic cells are monoblasts = Acute Monoblastic Leukemia (FAB M5a) If most monocytic cells are promonocytes = Acute Monoblastic Leukemia (FAB M5b)
Acute Erythroid Leukemia - FAB M6 ≥50% are erythroid precursors ≥20% are myeloblasts (this is what qualifies this as a leukemia Pure Erythroid Leukemia = 80% of marrow cells are erythroid
Acute Megakaryoblastic Leukemia - FAB M7 ≥50% of leukemic blasts are of the megakaryocytic lineage
Acute Basophilic Leukemia High amount of Basophils
Precursor B-Cell Neoplasms - FAB L1 Small lymphoblasts, uniform size, scant cytoplasm In children = 80-85% are B-cell In adults = 70% are B-cell ALL
Precursor T-Cell Neoplasms - FAB L2 Larger lymphoblasts, pleomorphic, abundant cytoplasm In children = 15% are T-cell ALL
Burkitt’s Type ALL - FAB L3 Lymphoblasts with intense basophilic cytoplasm and vacuoles Large lymphoblasts w abundant intense basophilic cytoplasm w prominent cytoplasmic vacuolization
Created by: nbechen3
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