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Leukocytes Unit

Abnormalities of Leukocytes and their associated diseases - Part 1

AbnormalityDescriptionAssociated Diseases
Auer bodies round or rod-like, 1-6 um long, red-purple, refractive inclusions in neutrophils Acute myelocytic leukemia
Chediak-Higashi anomaly Grey-green, large cytoplasmic inclusions resembling Dohle bodies Chediak-Higashi syndrome
Dohle bodies Small (1-2um) blue cytoplasmic inclusions in neutrophils infections or inflammatory diseases, burns, myelocytic leukemia, and myeloproliferative syndromes
Leukemic cells presence of lymphoblasts, myeloblasts, monoblasts, myelomonoblasts, promyelocytes (none seen in a normal peripheral blood smear) Leukemia (acute & chronic), leukemoid reaction, severe infectious or inflammatory diseases, myeloproliferative syndromes, malignancy, infectious mononucleosis, & myelophthisis.
May-Hegglin anomaly Basophilis RNA cytoplasmic inclusions of leukocytes. Similar to Dohle bodies May-Hegglin syndrome
Pelger-Huet anomaly Neutrophil with bi-lobed or no segmentation of nucleus. Chromatin is coarse and cytoplasm is pink with normal granulation. Hereditary; myelocytic leukemias, and myeloproliferative syndromes
Plasmacytosis Plasma cells are present (none normally seen in peripheral blood) Multiple myeloma, plasma cell leukemia, malignancy, chronic renal disease, aplastic anemia, TB; any severe infectious or inflammatory condition
Smudge cell Disintegrated lymphocyte Chronic lymphocytic leukemia
Toxic granulation Coarse black or purple cytoplasmic granules Infectious or inflammatory diseases
Alder's Anomaly Prominent azurophilic granulation in leukocytes; similar to toxic granulation Gargoylism and associated hereditary disorders
Created by: nbechen3