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Lymphocyte Unit
Types of Lymphocytes: Their Functions & Immunophenotypic Markers
Cell Type | Function | Markers |
---|---|---|
T Suppressor Cell | Switch off both B & T Lymphocytes attack mode when infection is over and recovery is done | CD2, CD5, CD7, CD8, CD3 |
Mature B Lymphocyte | Synthesis & release immunoglobulins (antibodies) Antibody Functions (Pathogen & Toxin Neutralization)(Classical compliment activation) (Opsonin promotion of phagocytosis & pathogen elimination. | CD19, CD20, CD22 Bright, CD45 Bright, SmIgM |
B Lymph Plasmocyte | Responsible for synthesis and excretion of immunoglobulins; Produce antibody specific to antigen that triggered the response. | CD19, CD20, CD45, CyIg, CD38, CD138, CD56 Low |
NK Lymphocyte - CD56 Dim | Produce increased levels of cytokines & chemokines; more effective in antibody-dependent cellular cytotoxicity (ADCC) & natural antibody-independent cytotoxicity | CD56 Dim |
NK Lymphocyte - CD56 Bright | Major cytokine producers when stimulated by proinflammatory cytokines (eg, IL-12, IL-15, & IL-18) that are stimulated by monocyte-derived cytokines; produces interferon gamma (kills & inhibits pathogens) | CD56 Bright |
T Helper Cell | Produce cytokine & chemokine to integrate immune response Stimulate B Lymphs antibody production; recruit the phils (Neutro, Eosino, and Baso) and macrophages to inflammation site for phagocytosis; Sensitized T cells protect against infections | CD2 , CD5, CD7, CD4, CD3, CD38 |