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Nerve Physiology

UCI Physio Test 1

QuestionAnswer
equation for how fast the membrane potential can change dV/dt=I/C
equation for how much charge needs to be stored in the membrane to maintain a given membrane potential V=Q/C
C is proportional to what s/d so dV/dt=Id/s
V is proportional to what Qd/s
hyperkalemia high levels of potassium in serum
hypokalemia low levels of potassium in serum
nernst equation for potassium V(k)=(RT/z(k)F)ln(K(o)/K(i))
nernst equation in usefull form for all ions V=(62/z)log(ion(o)/ion(i))
what is the current when Vm=Vion 0
electrochemical driving force V(m)-V(ion)
what is G(ion) conductance of the membrane for that ion G(ion)=NP(o)gamma (N is number of channels, P(o) is the % of channels open, and gamma is the conductance of a single channel
I(ion) equation I(ion)=G(ion)[V(m)-V(ion)] or replace G(ion) with NP(o)Gamma
general equation for V(m) V(m)=[Sum from i to n] G(i)V(i)/[Sum from i to n]G(i)
Na/K ATPase pumps what ratio 3 Na in for 2 K out
what sets the V(resting) for potassium leak channels
digoxin and ouabain cardiac glycosides pump inhibitors and increase heart contractility
palytoxin very toxic; binds to Na/K ATPase pump and locks it allowing free Na K transported
halothane and isoflurane general anesthesia gases that activate K+ leak channels, making neurons less excitable
lidocaine and procaine local anesthetics; block Nav channels
propofol (divrivan) short-acting hypnotic agent blocks Nav channels; used to induce and maintain general anasthesia
antiepileptic/anticonvulsant drugs inhibit Nav channels (phenytoin and carbamazepine)
antiarrhythmic drugs block delayed rectifier Kv channels (Dofetilide)
TTX and STX tetrodotoxin and saxitoxin; paralytic toxins; block Na channels
channelopathies diseases caused by altered fxn of ion channel (genetic or acquired)
synaptotagmin Ca++ sensor that links Ca++ channel activation to vesicle fusion
BoNT and TeNT action cleave the SNARE complex so that vesicle fusion can't occur
AchE degrades Ach
drugs that treat dementia in patients with Alzheimer target what AChE
Sarin nerve gas that inhibits AchE causes paralysis
ionotropic ion channel directly gated by the ligand neurotransmitter
metabotropic receptor that, upon neurotransmitter binding, initiates an intracellular signaling cascade
nicotinic AchR postsynaptic receptor at NMJ; made of 5 subunits- 2 alpha, beta, gamma, delta; both alpha sites must be bound for opening
reverse potential equation for the ESPS V(esps)=((Gamma(Na)/Gamma(K))V(Na) + V(K))/((Gamma(Na))/(Gamma(K))+1)
equation for Gamma Na/Gamma K GammaNa/GammaK=(Vepsp-Vk)/(Vna-Vepsp)
MEPP miniature end plate potential which occur randomly
probablility of NMJ firing from one AP 100%
probability of CNS firing from one AP low
curare non-depolarizing muscle relaxant that blocks nAChR
myasthenia gravis autoimmune disorder from antibodies that block nAChRs; treated with AchE inhibitors
type I CNS synapses glutamatergic (excitatory)
type II CNS synapses GABA (inhibitory)
Created by: droid