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KIN 3600

Lec 10

Cori cycle Lactate produced by a muscle and diffuses into the blood circulation; liver picks up and dehydrogenizes lactate to pyruvate then converts pyruvate back to glucose; glucose leaves liver back into circulation and muscle picks up glucose. G->P, P->Lac
How much lactate is oxidized following exercise? 70% -used as substrates by the heart and skeletal muscle
how much lactate is converted to glucose in the live? 20%
how much lactate is converted to amino acids in the liver? 10%
Type 2 muscle cells -lactate producing cell -Fast glycolytic fibers -Main metabolic pathway
1 lactate cause of fatigue -pH decreases inactivates enzymes, PFK, Fats -Muscle restricts fats by recombining FFA with glycerol
Following a lactogenic exercise, lactic acid is removed more rapidly with light exercise compared to passive rest during recovery
optimal intensity 30 – 40% VO2 max
No exercise Slow v blood lactate
Light exercise Faster v blood lactate concentrates
The main adaptations to short duration high intensity lasting less than 8-10 seconds (100m dash) ^ 25% ATP, 40% CP ^ fuel storage = ^ duration ^ 30% ATPase, 20% MK, 36% CPK Top speed remains SAME
Main adaptations to short duration high intensity training 20 to 60 sec -mainly fueled by anaerobic glycogenolysis - ^ muscular glycogen - ^ duration = improved performance - ^ 83% key glycolytic enzymes (PFK) - ^ top speed
Main adaptations to endurance training (800m-marathon) - ^ 26% myoglobin - ^ 120% number and 40% size of mitochondria - ^40% activity and concentration in TCA & ETC - ^ glycogen storage 2.5 x - ^ fatty acids utilization
Main adaptations to High-Resistance strength training (5 months) -28 % increase in strength -5.1 % increase in CP concentration -35.2 % increase in Creatine concentration -17.8 % increase in ATP concentration -32 % increase in Muscle Glycogen concentration
Steady state exercise constant unchanging
Maximal Exercises interval environment ^ till fatigue
Fastest system to supply energy ATP & CP
ATP v = v speed ATP ^ = ^ speed
Steady State O2 consumption curves linearly meets ATP demand keeping -1.5 L-min
O2 deficit How much oxygen should have been utilized to make exercise aerobically
Created by: rmart11