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outline 5

Comparative Physiology- Renner Lecture 5

what is required for passive transport? no energy. just a concentration gradient and/or chemical gradient across cell membrane as a driving force
what is rate of diffusion for lipid soluble substances dependent on? 1. number of H-bonds broken for water 2. substance lipid solubility
how does diffusion through aqueous channels occur? K+ (or ion) impinges on channel wall transporting across a resistance. levels off eventually
what are passive transport routes? 1. diffusion of lipid soluble substances 2. diffusion through aqueous channels 3. passive carrier-mediated transport
What is the criteria for passive-carrier mediated transport? 1.saturable, peaks then goes down 2. selective. presences of similar molecules won't affect the rate of transfer for a given carrier. 3. inhibited by competitive inhibitors, molecules similar to transported ones. 4. direct energy use not required
what are mechanisms for carrier mediated transport? 1. uniport 2. symport 3. antiport
what are Uniporters? Carriers that simply transport a molecule from one side of the membrane to the other
what kind of transporter is the glucose transporter found on RBC membrane? Uniporter that has an active site that binds glucose, brings in inside the cell and changes its conformation
What is a symport? a coupled transporter that uses electrical and/or chemical gradient to drive transport of another substance in the same direction. However, the transport s energetically unfavorable.
Give an example of a symport and explain how it works Transport of amino acids from invertebrate gut across intestinal mucosal cells to blood. Na+ has chem/elec driving force, X against conc gradient. Na+ binds to X, Na+ overcomes small force of X transporting it out the cell. Energy expense= Na+/K+ pump
What is an Antiport? couples transporter that transports substances in the opposite direction. Exchange involves ions having the same charge across opposite sides of the membrane.
give an example of an antiport Bicarbonate-chlorine transporter. Bicarbonate and chlorine both have -1 charge 1 bicarbonate in, 1 chlorine ion out
what is the importance of an antiport ? maintains electrical balance across membrane because both substances have the same charge
Created by: rusulali97