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outline 4
Comparative Physiology- Renner Lecture 4
Term | Definition |
---|---|
Diffusion | net movement of molecules from a region of high concentration to a region of low concentration |
Concentration gradient (C) | the difference in solute concentration between the two compartments |
net rate of diffusion. | the difference between random movements from one side of a membrane to the other (depends on concentration gradient aka driving force for diffusion) |
Fick's law of diffusion | Q= deltaC.P.A/mw(solute).x |
Osmosis | diffusion of water across a semi permeable membrane along its concentration gradient. Presence of solute decreases concentration of water (bc high conc of solute). |
when does the system reach equilibrium? | when hydrostatic pressure=osmotic pressure |
hydrostatic pressure (water pressure) | pressure exerted by water. Def from google |
tonicity | relationship between solute concentrations between compartments |
how can osmotic pressure be quantified? | by knowing the concentrations of osmotically active particles |
isotonic | same concentration in the 2 compartments |
hypotonic | less concentrated relative to the solute. Water concentration is higher. |
hypertonic | higher number of solute molecules, lower concentration of water. |
membrane's key features with respect to membrane potential | presence of channels that allow K+ diffusion, minimal diffusion of Na+, membrane is impermeable to protein A- |
law of electroneutrality | bulk solutions have a balance of +/- charge |
how does diffusion of K+ occur? squid axon | passive (no ATP) across aqueous pores across membrane formed by protein channels |
Na+/K+ pump, why is it important? | prevents the loss of concentration gradients of Na+ and K+ when K+ is lost and Na+ is entered. Prevents concentration gradient from diminishing. |
how does Na+/K+ work? | originally Na+ is favored to go in to the cell because the concentration of it outside the cell is higher. K+ is favored outside the cell because it has a high concentration on the outside. Na+/K+ uses ATP active transport to get 3 Na+ out, 2 K+ in |
what is Na+/K+ pump composed of? | 2 subunits, catalytic subunit alpha, and glycoprotein beta in a alpha2beta2 arrangement. |
depolarization, how it affects Na+/K+ pump | making the inside of the cell more positive with respect to the outside. (normally inside is negative). it increases pump rate. |
accounts for 33% of energy use by cell? | Na+/K+ pump |