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Chapter 7
introduction to the Endocrine system
| Question | Answer |
|---|---|
| the study of hormones is called_____________. | |
| List the 3 basic ways hormones act on their target cells | |
| for a chemical to be defined as a hormone, it must be secreted into the __________ for transport to a(n) _________and take effect at ________concentrations. | |
| what is meant by the term half-life in connection with the activity of hormone molecules? | |
| Metabolites are inactivated hormone molecules, broken down by enzymes found primarily in the _________found primarily in the _______ and ______, to be exerted in the ______ and______ respectively. | |
| candidate hormones often have the word ________ as part of their name. | |
| why do steroid hormones usually take so much longer to act than peptide hormones. | |
| when steroid hormones act on the cell nucleus, the hormone-receptor complex acts as a(n)____________ factor, binds to DNA, and activates one or more __________, which create mRNA to direct the synthesis of new ___________. | |
| What happens when you're thirsty or slightly dehydrated? | ADH levels rise. Your kidneys reabsorb more water and put out concentrated urine. If you've had plenty to drink, ADH levels fall and what comes out is clears and dilute. |
| What happens when your body doesn't make enough ADH? | this condition is called central diabetes insipidus. If you make enough but your kidneys can't respond to it, you have nephrogenic diabetes insipidus. |
| what controls rate of enzymatic reactions, transport of ions or molecules across cell membranes, and gene expression and protein synthesis? | Hormones |
| what do pheromones do? | They elicit physiological or behavioral response on other organisms of the same species |
| Cellular mechanism of action depends on... | binding to target cell receptors |
| True or False: A trophic hormone control the secretion of another hormone. | True |
| What are the 3 integrating centers? | Hypothalamic stimulation- from CNS Anterior pituitary stimulation-from hypothalamic trophic hormones Endocrine gland stimulation- from anterior pituitary trophic hormones (except prolactin) Cortisol |
| Synergism.. | combined effect is greater than the sum of individual effects |
| Permissiveness need... | second hormone to get full effect |
| Antagonism is when | one substance opposes the actions of another |
| Hypersecretion: | excess hormone |
| Hypersecretion is caused by... | tumors or exogenous iatrogenic treatment (Negative feedback may lead to atrophy of gland) |
| Hyposecretion: | deficient hormone |
| Hyposecretion is caused by... | decreased synthesis materials or atrophy (absence of negative feedback leads to overproduction of trphic hormones) |
| What are some receptor and signal transduction abnormalities? | Missing or nonfunctional receptors androgen insensitivity syndrome pseudohypothyroidism |