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MLT tox,TDM

TDM, toxicology, and tumor markers

QuestionAnswer
a blood sample for a trough drug level should be drawn shortly before drug administration
This is not a reason to monitor drug levels to detect the presence of potential interferences
carbamazepine, primidone, and valproic acid are all examples of antiepileptic drugs
Clearance (CL) of a drug is defined as the rate of elimination by all routes normalized to the concentration of drug in some biological fluids
commercially prepared radiator fluid contains a significant amount of ethylene glycol
Depakene or Depakote are proprietary names for valproic acid
diagnostic specificity is defined as the probability that a laboratory test will be negative in the absence of disease
ethanol metabolizes to acetic
ethylene glycol metabolizes to oxalic acid
imipimine is classified as tricyclic antidepressant
in thin layer chromatography, Rf is defined as the distance traveled by the drug divided by the distance traveled by the solvent
in what disorders would the maternal serum level of a1-fetoprotein be elevated neural tube defect
increased serum peak and trough levels of aminoglycosides are often associated with toxic effects to the kidney
ingestion of acetylsalicylic acid (aspirin) is associated with what condition Reyes syndromes
Lead exposure causes an increased blood concentration in what analyte Zinc-protoporphyrin
Levels of 89% carboxyhemoglobin saturation of whole blood are commonly found in fatal carbon monoxide poisoning
methotrexate is a drug used for management of lymphoblastic leukemia in children
phenobarbital is classified as a sedative and hypnotic
salicylism is described as the following a syndrome associated with tinnitus (a high-pitched buzzing noise in the ears), vertigo, decreased hearing, and occasionally nausea and vomiting
screening methods for drug abuse testing requires what characteristic they must be analytically sensitive
what are the four correct pharmacological parameters that determine serum drug concentration Absorption, distribution, metabolism, excretion
THC is the principal active metabolite in what drug marijuana
The pharmacological response of a drug is initiated when the drug is in what form? bound to fatty acids bound to proteins bound to carbohydrates free Free
the production of alpha fetal protein (AFP) in a healthy individual is best reflected by the production of AFP declines rapidly at birth and healthy adults and children have negligible or undetectable levels in serum
the reason that carbon monoxide is so toxic is because it has 200-250 times the affinity of oxygen for hemoglobin binding sites
urine adulteration test strips are designed to detect which of the following bleach nitrites creatinine all of these all of these
valium and Librium are examples of which of the following classes of drugs benzodiazepines opiates barbiturates amphetamines benzodiazepines
what is the clinical usefulness of measuring carcinembryonic antigen monitoring for recurrence of colon cancer
which molecular form(s) is/are measured by an intact beta-hCG assay? hCG core and "nicked hCG or hCGn the whole molecule only "nicked" hCG or hCGn alpha-hCG and free beta-hCG subunits the whole molecule
which of the following assays is recommended as a screening test for colorectal cancer in persons over 50 y.o. Fecal trypsin AFP BTA Occult blood test Occult blood test
Which of the following biological fluids is the specimen of choice for screening and/or analyzing drugs of abuse? serum whole blood urine CSF urine
which of the following biomarkers are elevated in advanced stages of breast cancer? CA 15-3 and CA549 Total and free PSA CEA and alpha-fetoprotein DUPAN-2 and Gastrin CA 15-3 and CA 549
Which of the following biomarkers is elevated in nonmucinous epithelial ovarian cancer? CA15-3 CA19-9 CA 125 CEA CA 125
Which of the following classes of compounds has a sedative effect and is used to treat anxiety? Amphetamines Opiates Cannabinoids Benzodiazepines Benzodiazepines
Which of the following compounds is a cardiac glycoside that is used in the treatment of congenital heart failure and arrhythmia by increasing the force and velocity of myocardial contraction? digoxin carbamazepine amikacin phenobarbital digoxin
which of the following compounds is an anticonvulsant used to control tonic-clonic (grand mal) seizures? digoxin acetaminophen lithium phenytoin phenytoin
which of the following compounds is the major metabolite of primidone digoxin thorphylline N-acetylprocainamide phenobarbital phenobarbital
which of the following compounds relaxes the smooth muscles of the bronchial passages acetaminophen lithium phenytoin theophylline theophylline
which of the following compounds selectively inhibits proliferation and activation of CD4+T cells Digoxin Beta hCG Progesterone Cyclosporine A Cyclosporine A
Which of the following is FALSE about PSA? It is a single-chain glycoprotein It is used as a tumor marker It is not elevated in benign prostatic hyperplasia It is quantified in serum by immunoassays It is not elevated in benign prostatic hyperplasia
Which of the following is an example of an antiarrhythmic drug that has a metabolite with the same pharmacological action? procainamide phenobarbital quinidine caffeine procainamine
Which of the following is bactericidal for Streptococci, Corynebacteria, Clostridia, Listeria, and Bacillus species? Tobramycin Cyclosporine Vancomycin Methotrxate Vancomycin
Which of the following must be determined to calculate diagnostic specificity? True-negatives, and false-positives True-positives and false-positives true-positives and false-negatives true-negatives and false-negatives true-negatives and false-positives
Which of the following techniques is a definitive means for both qualitative and quantitative analysis of drugs of abuse Thin layer chromatography Gas chromatograph coupled with mass spectrometry spectrophotometry osmometry gas chromatography coupled with mass spectrometry
Which tumor marker is associated with cancer of the urinary bladder CA 125 CA 19-9 CA50 Nuclear matrix protein nuclear matrix protein
Created by: Mwortman