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MLT Hepatic 2
Hepatic from lecture
| Question | Answer |
|---|---|
| Liver is the major site of storage for | iron, glycogen and lipids |
| liver plays an important role in getting rid of waste products such as | bilirubin ammonia and urea |
| Indicators of metabolic function decreased albumin functions are due to | decreased synthesis by the liver |
| ascites is due to | decreased oncotic pressure |
| increased prothrombin time is | increased clotting time |
| most clotting factors are produced by | the liver |
| ammonia is very toxic to the | brain |
| bilirubin is derived from the breakdown of | hemoglobin |
| a majority of enzymes are | intracellular |
| when tissue damage occurs enzymes are released | into the plasma |
| the most sensitive tests for the liver are | enzyme tests |
| hemoglobin in RBCs forms | heme + iron + protein |
| heme is converted to | unconjugated (indirect) bilirubin |
| unconjugated (indirect) bilirubin is ____ and will attach to ________ to be transported to the __________ | insoluble albumin liver |
| unconjugated bilirubin can not be excreted in the _______ in this form | urine |
| bilirubin is transported to the liver and combines with ______ by the enzyme to form | glucuronic acid glucuronyl transerase conjugated (direct) bilirubin |
| conjugated (direct) bilirubin is water _________ | soluble |
| the majority of conjugated bilirubin produced in the liver is transported into the | bile ducts and intestinal tract |
| in the GI tract bacterial enzymes convert the conjugated bilirubin to | uroilinogen |
| urobilinogen forms ______ which gives the feces its brown color | urobilin |
| Total bilirubin reference range | 1.0mg/dL or less |
| urine bilirubin reference range should be | negative |
| signs and symptoms of jaundice serum bilirubin is | greater than 3mg/dL |
| signs and symptoms of jaundice serum appearance is | icteric |
| prehepatic jaundice is also known as | hemolytic jaundice |
| hepatic jaundice involves the _______ conversion of unconjugated bilirubin to conjugated bilirubin by the liver | decreased |
| posthepatic jaundice is also known as | obstructive jaundice |
| in pre and post hepatic jaundice the function of the liver | is not impaired |
| In prehepatic jaundice an increased destruction of _______ exceeds the ability of the liver to conjugate and excrete bilirubin. | RBCs |
| Causes of prehepatic jaundice are | hemolytic anemias transfusion reactions hemolytic disease of newborn |
| lab findings for prehepatic jaundice include ______ total bilirubin ______ indirect or unconjugated bilirubin ______urine bilirubin ______fecal urobilinogen ______retic count | increased: total bilirubin increased: indirect or unconjugated bilirubin negative: urine bilirubin increased: fecal urobilinogen increased: retic count |
| Hemolytic Disease of the Newborn is usually due to the _____ incompatibility of the mother and child | Rh |
| _____ levels of indirect bilirubin due to excessive breakdown of baby's RBCs | increased |
| when baby's unconjugated bilirubin levels reach greater than ___________ bilirubin is either unbound or loosely bound to albumin | 15-20mg/dL |
| loosely bound of unbound unconjugated bilirubin has a high affinity for | brain and CNS tissue |
| bilirubin deposited in the brain tissue causes irreversible brain damage called | kernicterus |
| monitor baby's _____ as well as ______ levels very closely | albumin bilirubin |
| hepatic jaundice is the failure to | conjugate bilirubin |
| hepatic jaundice has defective transport | in or out of hepatocyte |
| hepatic jaundice lab values _______ depending on disease process | vary |
| hepatic retention jaundice is the defective transport of _______ into _________ | bilirubin hepatocyte |
| hepatic retention jaundice Physiologic jaundice of newborn | baby's glucuronyl transferase system not fully developed, especially in premies |
| hepatic retention jaundice Chronic liver disease | liver eventually loses its ability to conjugate |
| Lab findings for Hepatic Retention Jaundice ____indirect bilirubin urine bilirubin ______ | increased negative |
Created by:
Mwortman
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