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RNA viruses
Mod 5 lec 2
Question | Answer |
---|---|
Arenavirus | ss, envelope, helical capsid, meningitis, rodent resevoir, BIo level4 |
Bunyavirus | ss, envelope, helical capsid, encephalitis, hantavirus, not isolated in lab |
calicivirus | ss, no envelope, icosahedral, norovirus and Norwalk virus |
Coronavirus | ss, envelope, pleomorphic/spherical capsid with large club-shaped projections, SARS and common cold |
Filovirus | ss, helical, long and slender, monkey reservoir, bio-level4, Ebola |
Flavivirus | ss, envelope, icosahedral, hepatic diseases- yellow and dengue fever, west nile virus, HCV |
HCV | only human vector, serology- EIA, western blot, RIBA, also by molecular |
Orthomyxovirus | ss, segmented, helical capsid, envelope. Replicated in cytoplasm. Neuraminidase and hemagglutinin surface ags- flu |
Influenza | A,B,C segmented genome allows for heavy reassortment N, H ags provide subtpye. Cultured using CPE, hemadsorption |
Paramyxovirus | ss, helical, envelope, replicate in nucleus and cytoplasm. mumps, measles, RSV, parainfluenza |
Parainfluenza | resp infection, 4 antigenic types, throat swab, cell culture w/ hemaadsorption |
measles | maculopapular rash, fever, resp disease. culture w/ hemadsoption |
mumps | infects partoid salivary glands, also testis, ovaries, kidney. throat swab or urine, ID'ed with hemadsorption |
RSV- respiratory syncytial virus | bronchioltis, pneumonia in infants. Produces typical CPE, rapid tests, confirm with monoclonal ab |
Metapneumovirus | Acute resp tract infections in adults and children. PCR for diagnosis, annual in winter/spring |
Picornavirus | ss, very small, icosahedral, no envelope, replicate in cytoplasm |
Rhinovirus | common cold, can be cultured, acid sensitive, only URT, limited growth at 37c |
HAV | fecal/oral transmission, no cell culture, diagnose with serology |
Reovirus | Respiratory Enteric Orphan. ds, no envelope, icosahedral, replicates in cytoplasm, infantile diarrhea, ELISA diagnosis |
Retrovirus | ss, envelope, RT(reverse transcriptase), integrates into genome, replicates in cytoplasm and nucleus |
HIV | cylindical or conical shape, infects CD4 cells, ELISA and Western blot. secondary diseases- CMV, Kaposi's sarcoma, pneumosistic pneumonia |
Rhabdovirus | ss, bullet shaped, replicates in cytoplasm, rabies |
Rabies | infected animals, effects CNS, incub 2-6wks. diagnosed in suspect animal bu immunofluorescence of brain tissue |
Togavirus | ss, envelope, icosahedral, rubella |
Arbovirus | E and W equine encephalitis, bird resevoir- mosquito vector. culture possible but ususally diag by serology |
Rubella | droplet transmission, mild disease in children, causes birth defects if occurs during pregnancy. usually serology but can be cultured |