Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.

Remove Ads
Don't know
remaining cards
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards

Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Anti-fungal drugs

Mod5 lec1

methods of susceptibility testing macro-broth dillution
AB biodisk interpretation flucytosine- almost complete inhibition 95%
Automated system for yeast susceptibility TREK Sensititre YeastOne- microdillution method
Technical variables in susceptibility testing inoculum, media, incubation, end-points
Issues with anifungal drugs solubility, chemical stability, mode of action, partial inhibition, narrow MIC's
Five groups of anti-fungal agents polyenes, azoles, antimetabolites, echinocandins, anti-mitotic
polyenes amphotericin B
amphotericin B mode of action inserts itself into cell membrane by attaching to ergosterol forming pores through which cytoplasm leaks out
Azoles fluconazole, itraconizole, ketoconazole, voriconizole, posiconazole, ravuconizole
Azole mode of action attacks cytochrome enzyme P450 which converts lanosterol to ergostrerol. Cannot synthesize new cell membrane
Anti-metabolite flucytosine
Flucytosine mode of action converts to 5-fluorouracil which inhibits RNA and protein synthesis
Echinocandin caspofungin, micafungin, anidulafungin
Eichocandin mode of action inhibits synthesis of 1,3,B-glucan. Can not form cell wall
Anti-mitotic griseofulvin
Griseofulvin mode of action disrupts mitotic spindle formation
Griseofulvin delivery system taken orally- absorbs in skin layers- as it moves out it disrupts superficial mycotic infection. slow-working/ hepatotoxic
Created by: kmaemom