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Anti-fungal drugs

Mod5 lec1

QuestionAnswer
methods of susceptibility testing macro-broth dillution
AB biodisk interpretation flucytosine- almost complete inhibition 95%
Automated system for yeast susceptibility TREK Sensititre YeastOne- microdillution method
Technical variables in susceptibility testing inoculum, media, incubation, end-points
Issues with anifungal drugs solubility, chemical stability, mode of action, partial inhibition, narrow MIC's
Five groups of anti-fungal agents polyenes, azoles, antimetabolites, echinocandins, anti-mitotic
polyenes amphotericin B
amphotericin B mode of action inserts itself into cell membrane by attaching to ergosterol forming pores through which cytoplasm leaks out
Azoles fluconazole, itraconizole, ketoconazole, voriconizole, posiconazole, ravuconizole
Azole mode of action attacks cytochrome enzyme P450 which converts lanosterol to ergostrerol. Cannot synthesize new cell membrane
Anti-metabolite flucytosine
Flucytosine mode of action converts to 5-fluorouracil which inhibits RNA and protein synthesis
Echinocandin caspofungin, micafungin, anidulafungin
Eichocandin mode of action inhibits synthesis of 1,3,B-glucan. Can not form cell wall
Anti-mitotic griseofulvin
Griseofulvin mode of action disrupts mitotic spindle formation
Griseofulvin delivery system taken orally- absorbs in skin layers- as it moves out it disrupts superficial mycotic infection. slow-working/ hepatotoxic
Created by: kmaemom