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Blood Banking

Process of removing the antibody from serum sample Adsorption
Force of attraction beteeen 1 Fab and 1 epitope Affinity
1 or 2 or more different genes that may occupy a specific locus on a chromosome Allele
Special class of immumogen that induces hypersensitivity reaction Allergen
Gene that does not produce a detectable product Amorph
Any substance Protein or nonprotein that when introduced into an animal causes production of an antibody Antigen
Aggregates of histiocytes are seen in acute rheumatic fever Aschoff Bodies
An antibody produced in response to an antigen possessed by the same individual Autoantibody
Antigenic substance found within the same individual Autologous
Sum of all attractive forces between a multivalent antibody to a multivalent antigen Avidity
Thermolabile protein present in normal animal serum Complement
Genetic combination where both genes at a single loci are expressed Codominant
Characteristic of an antibody to react stronger with cells that have a homozygous presentation of an antigen Dosage
Discovered the process of vaccination Edward Jenner
Process used to remove antibodies bound to RBCs Elution
Ratio of antigen dilution to antibody dilution at which maximum precipitation occurs Equivalence Zone
Total genetic composition of an individual, representing maternally and paternally derived genes Genotype
Acting like an antigen when coupled with a protein carrier but incapable by itself of stimulating antibody formation Hapten
Portion of immunoglobulin molecule important for maintaining the correct orientation of the arm of the antibody in relation to its binding with the antigen Hinge region
Any substance that can induce an immune response (not necessarily Ab production) Immunogen
Subtype of immunoglobuli classes Isotype
Immune competent cells Lymphocytes
Substances that are produced by activated T lymphocytes that participate in various cell mediated immunity Lymphokines
Antigen presenting or processing cell Macrophage
Blood transfused is equal to recipient's blood volume Massive Transfusion
Area in the lymph node where the plasma cells predominate when a state of localized infection occurs Medulla
Substance in serum that promotes immune adherence and facilitates phagocytosis by the reticuloendothelial system Opsonin
Immunologic procedure in whoch antibody and antigen are placed in wells of a gel medium plate and allowed to diffuse in order to visualize the reaction by a precipitin line Ouchterlony
Detectable or expressed characteristics of genes Phenotype
Immediate precusor of antibodies Plasma cells
Phenomenon of antigen excess Postzone
Responsible for the flexibility of the hinge region of the immumoglobulin Proline
Phenomenon of antibody excess Prozone
"Stack of coins" appearance of red cells Rouleaux Formation
Measure of the strength of an antibody by testing its reactivity at increasing dilutions against the appropeiate antigen. The reciprocal of the highest dilution that shows agglutination. Titer
Substances added to an immunogen to enhance immune response by: -prolonging retention time -increasingthe effective size of immunogen -stimulating the influx of macrophages and/or lymphocytes Adjuvants
A.) Monomer; predominant/highest concentration Ab in immune serum globulin preparation due to having the longest half life; responsible for 2ndary (anamnestic) immune response;associated with HLA B.) 4 Isotypes of this Immunoglobulin Subclass A.) IgG B.) 1, 2, 3, 4
Function of IgG: A.) Provide immunity to the newborn 1.) isotype/s cross placenta 2.) best isotype B.) Best in complement activation C.) Best in agglutination D.) Best in precipitation A.1. All except IgG2 A.2. IgG1 B. IgG3 > IgG1 > IgG2 C. IgM D. IgG
Monomer (serum IgA) and dimer (secretory IgA); associated with transport piece of secretory component produced by epithelial cells near IgA producing Ab plasma cells which functions to prevent enzymatic degradation of IgA; Ab found in secretions; IgA
Most common antibody deficiency IgA
Pentamer; responsible for 1° immune response, neutralization of toxins & viruses, opsonization & agglutination reactions; best in complement activation; IgM
May be present in amniotic fluid if there is infection; first to appear in the surface of B-cell; first produced by an infant; destroyed by sulfhydryl compounds: DTT & 2-ME that target disulfide bonds of J chain IgM
Abundant in immunocompetent but unstimulated B-cells; second to appear in B-cell; has activity against penicillin & insulin IgD
IgD main function Immunoregulation
Has reaginic activity and affinity to mast cells and basophils causing release of histamine; increased in parasitic infections, allergic/anaphylactic reactions IgE
Created by: AriMasu