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Blood Banking
| Question | Answer |
|---|---|
| Process of removing the antibody from serum sample | Adsorption |
| Force of attraction beteeen 1 Fab and 1 epitope | Affinity |
| 1 or 2 or more different genes that may occupy a specific locus on a chromosome | Allele |
| Special class of immumogen that induces hypersensitivity reaction | Allergen |
| Gene that does not produce a detectable product | Amorph |
| Any substance Protein or nonprotein that when introduced into an animal causes production of an antibody | Antigen |
| Aggregates of histiocytes are seen in acute rheumatic fever | Aschoff Bodies |
| An antibody produced in response to an antigen possessed by the same individual | Autoantibody |
| Antigenic substance found within the same individual | Autologous |
| Sum of all attractive forces between a multivalent antibody to a multivalent antigen | Avidity |
| Thermolabile protein present in normal animal serum | Complement |
| Genetic combination where both genes at a single loci are expressed | Codominant |
| Characteristic of an antibody to react stronger with cells that have a homozygous presentation of an antigen | Dosage |
| Discovered the process of vaccination | Edward Jenner |
| Process used to remove antibodies bound to RBCs | Elution |
| Ratio of antigen dilution to antibody dilution at which maximum precipitation occurs | Equivalence Zone |
| Total genetic composition of an individual, representing maternally and paternally derived genes | Genotype |
| Acting like an antigen when coupled with a protein carrier but incapable by itself of stimulating antibody formation | Hapten |
| Portion of immunoglobulin molecule important for maintaining the correct orientation of the arm of the antibody in relation to its binding with the antigen | Hinge region |
| Any substance that can induce an immune response (not necessarily Ab production) | Immunogen |
| Subtype of immunoglobuli classes | Isotype |
| Immune competent cells | Lymphocytes |
| Substances that are produced by activated T lymphocytes that participate in various cell mediated immunity | Lymphokines |
| Antigen presenting or processing cell | Macrophage |
| Blood transfused is equal to recipient's blood volume | Massive Transfusion |
| Area in the lymph node where the plasma cells predominate when a state of localized infection occurs | Medulla |
| Substance in serum that promotes immune adherence and facilitates phagocytosis by the reticuloendothelial system | Opsonin |
| Immunologic procedure in whoch antibody and antigen are placed in wells of a gel medium plate and allowed to diffuse in order to visualize the reaction by a precipitin line | Ouchterlony |
| Detectable or expressed characteristics of genes | Phenotype |
| Immediate precusor of antibodies | Plasma cells |
| Phenomenon of antigen excess | Postzone |
| Responsible for the flexibility of the hinge region of the immumoglobulin | Proline |
| Phenomenon of antibody excess | Prozone |
| "Stack of coins" appearance of red cells | Rouleaux Formation |
| Measure of the strength of an antibody by testing its reactivity at increasing dilutions against the appropeiate antigen. The reciprocal of the highest dilution that shows agglutination. | Titer |
| Substances added to an immunogen to enhance immune response by: -prolonging retention time -increasingthe effective size of immunogen -stimulating the influx of macrophages and/or lymphocytes | Adjuvants |
| A.) Monomer; predominant/highest concentration Ab in immune serum globulin preparation due to having the longest half life; responsible for 2ndary (anamnestic) immune response;associated with HLA B.) 4 Isotypes of this Immunoglobulin Subclass | A.) IgG B.) 1, 2, 3, 4 |
| Function of IgG: A.) Provide immunity to the newborn 1.) isotype/s cross placenta 2.) best isotype B.) Best in complement activation C.) Best in agglutination D.) Best in precipitation | A.1. All except IgG2 A.2. IgG1 B. IgG3 > IgG1 > IgG2 C. IgM D. IgG |
| Monomer (serum IgA) and dimer (secretory IgA); associated with transport piece of secretory component produced by epithelial cells near IgA producing Ab plasma cells which functions to prevent enzymatic degradation of IgA; Ab found in secretions; | IgA |
| Most common antibody deficiency | IgA |
| Pentamer; responsible for 1° immune response, neutralization of toxins & viruses, opsonization & agglutination reactions; best in complement activation; | IgM |
| May be present in amniotic fluid if there is infection; first to appear in the surface of B-cell; first produced by an infant; destroyed by sulfhydryl compounds: DTT & 2-ME that target disulfide bonds of J chain | IgM |
| Abundant in immunocompetent but unstimulated B-cells; second to appear in B-cell; has activity against penicillin & insulin | IgD |
| IgD main function | Immunoregulation |
| Has reaginic activity and affinity to mast cells and basophils causing release of histamine; increased in parasitic infections, allergic/anaphylactic reactions | IgE |
Created by:
AriMasu
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