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Explain the difference between an 'antigen' and an 'epitope'. An epitope is a small sub unit on the surface of an antigen which binds to the antibody. An antigen is a carrier molcules which generates the immune response.
Which surface marker is involved in presenting antigenic epitopes on the surface of B cells? MHC2 complex.
Name the surface markers present on T cells which help them interact with B cells. TCR/CD4.
Which cell type releases cytokines? T cells.
Describe the role of a cytokine in activation of B cells. - Stimulates antibody production - Stimulates class switching - Stimulates proliferation of B cells - Stimulates the differentiation of plasma cells.
Which cell type undergoes clonal proliferation? B cells.
What triggers clonal proliferation? Epitopes binding to BCR.
Name the type of bonds which stabilize an antibody's structure? Disulphide bonds.
How many variable domains and how many constant domains does each heavy chain in IgG possess. 1 variable and 3 constants.
List the four factors which contribute to the diversity of antigen binding sites. - Variety of different genes - High somatic mutation rate - Splicing - Coded on different chromosomes.
List 4 variables that would make a molecule immunogenic. -High molecular weight -Chemical composition (complex) -Degradability of antigen -Foreignness to host.
Name a molecule used in the process of conjugation. MAP
List the type of chemical bonds involved in holding the antigens in a binding site on an antibody molecule. -van der waals -hydrophobic -hydrogen -electrostatic
Created by: hozzaaaa