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define atherosclerosis it is a disease where plaque forms in your arteries
charactersitics irregular lipid deposits in intima of large/medium arteries - core made out of cholesterol ester - surrounding area - fibrosis and calcification
consequences of atherosclerosis haemmorage into plaque, narrowing lumen of artery - low blood flow - thrombosis
risk factors advanced agemalesmokingdiabetes mellitushypertension
risk factors on biochemical level apo b100,a1,eLCAT;ACATlipoprotein lipase
clinical implications myocardial infarctionsenile dementiagangrenesstroke
treatment correct lifestyle, proper diet, drugs which INC HDL and DEC VLDL AND LDL eg. statin - inhibits hmg coa reductase + niacin - decrease vldl formation
T/F -endothelial damage causes the endothelial cells to adhere to LDL TRUE
t/f macrophages then consume lipoproteins then form CYTOKINES FALSE
T/F - macrophages consume lipoproteins and then form foam cells TRUE
what do foam cells secrete...? CYTOKINES - for attraction of other macrophagesGROWTH FACTORS - proliferation of smooth muscle cells and fibroblasts
smooth muscle cells then produce ___________and take up __________ to become foam cells collagen lipids
Created by: ahmeda101