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BB 451

Citric acid cycle

Step 1 CAC Citrate synthase, oxalcetate (OAA) and acetyl CoA join by aldol condensation at OAA C2 (carbonyl group); subsequent cleavage of citryl CoA thioester bond drives reaction. citrate synthase reaction example of ordered substrate binding
Step 2 CAC aconitase isomerizes citrate to isocitrate, the C-3 moves to C-2 position
Step 3 CAC isocitrate DH oxidatively decarboxylates isocitrate. two electrons removed to form NADH+ and H+, caboxyl leaves as CO2
step 4 CAC a-ketoglutarate DH oxidatively decarboxylates a-KG. NADH+ and H+ is produced and a 4-C succinyl group is generated, reaction scheme is identical to pyruvate DH
step 5 CAC succinyl CoA synthetase produces succinate and GTP. a substrate level phosphorylation is coupled to cleavage if succinyl-CoA thioester bond. involves a phosphohistidine intermediate
step 6 CAC succinate is oxydized to fumarate by succinate dehydrogenase. electrons captured by FAD rather than NAD. enzyme is anchored to matrix face of inner mitochondrial membrane. part of electron transport system
Step 7 CAC Fumarase catalyzes the stereospecific hydration of the C2 and C3 double bond of Fumarate formung L-Malate
Step 8 CAC Malate DH oxidizes malate. NADH + H+ is produced and oxaloacetate is regenerated. energetically unfavorable under standard conditions, but occurs in vivo because of exergonic upstream and downstream rxns
symmetric molecules acted on asymmetrically citrate, aconitase moves OH specifically to C2, fumarate, fumarase adds water such that only L-malate is formed
Created by: adam87
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