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Oncology Labs
Oncology
Question | Answer |
---|---|
Auer rods | AML |
Reed-sternberg cells | Hodgkins lymphoma |
Tear-drop shaped RBCs on peripheral smear: | Myelofibrosis |
Smudge cells | CLL |
Lytic lesions on bones, pathologic fractures, hypercalcemia, renal fail 2/2 lt chain excretion = | Multiple Myeloma |
Rouleaux formation = | Multiple Myeloma |
M-spike on SPEP = | Multiple Myeloma |
Bence–Jones proteins | Multiple Myeloma |
Dx imaging for Multiple Myeloma | Skeletal survey (not Bone scan) |
classic triad for Multiple Myeloma | Plasmacytosis, lytic bone lesions, serum/urine M-protein |
Suspected Lymphoma: dx studies | Lymph node bx; Bone marrow Bx; CT scan used for staging |
Hallmark of acute leukemia: | pancytopenia w/circulating blasts (>20% nuc cells in BM) |
acute leukemia dx studies: | hyperuricemia; +BM bx; high WBC; ALL: terminal deoxynucleotidyl transferase, mediastinal mass on CXR |
hallmark of CLL = | isolated lymphocytosis (>20,000 WBC); also see inc mature small lymphs, smudge cells |
hallmark of CML = | leukocytosis (150,000 WBC); also see anemia & high plts |
BCR-ABL by PCR = | CML (has replaced Phila chromosome ID to est dx) |
Blasts in BM <20%; Pelger-Huet cells (bi-lobed neutrophils) seen in: | MDS |
Multiple myeloma: BM bx shows: | q13- chromosome abnormality |
Part of eval for multiple myeloma (if elevated = very poor outcome) | Beta-2 microglobulins |
LAP = | leukocyte alkaline phosphatase; Low in CML; High in leukemoid reactions |
Fried egg appearance of cells (abundant cytoplasm & projections) = | hairy cell |
Hypogammaglobulinemia seen in: | CLL |
Anemia seen in which leukemias | MM, hairy cell (NOT in CML) |
Hodgkin Dz dx | CT chest, abdomen, pelvis; PET scan; BM bx |
NHL staging | CT chest, abdomen, pelvis; poss PET scan; BM bx; LDH (tumor marker); LP if CNS dz is suspected |
Osteochondroma on imaging | Lesion with peripheral rim of calcification and stippled calcification within lesion |
AFP (alfa fetoprotein) is a marker for: | HCC (liver), testicular ca |