Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.

Remove ads
Don't know
remaining cards
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards

Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Hemo Labs


Schilling test 2-step test using radiolabeled B12 to test for pernicious anemia
Schistocytes; MAHA; high LDH; low platelets; ADAMTS13-auto antibodies; neg Coombs = TTP
TTP labs Normal PT, PTT, fibrinogen. Platelets <20,000. High LDH. MAHA (schistocytes, helmet cells, NRBCs). ADAMTS13-auto antibodies. Neg Coombs
Glanzmann labs normal ristocetin (von W or B-S abnormal); abnl ADP, collagen, thrombin (opp von W or B-S)
DIC labs +D dimer, +FSP; low fibrinogen; PTT prolonged more often than PT, but PT goes out 1st (FVII short half life)
Fe def anemia labs low H&H/MCV, aniso & poikilocytosis, TIBC increases; ferritin <30, serum Fe <30, transferrin saturation <15%; high plts in severe
thalassemia labs Hgb H: lower Hct. Hgb H & beta thal: increased retic (alpha: normal); Normal Fe/ferritin. Basophilic stippling & NRBCs
thalassemia: blood smears alpha: target/acanth; Hgb H: target/poik; beta: target, poik (NRBCs in major)
sideroblastic anemia labs Hct 20-30, high serum Fe, low MCV, hypochromic; BM eval to est dx (sideroblasts); HSM; baso stippling in Pb tox
N/N anemia labs nml-high BM iron stores/ serum Fe/ferritin, nml-low TIBC
macro anemia 2/2 folate def: labs serum folate <150 ng/mL (daily diet req 50-100 mg/dL); macro-ovalocytes, H-J bodies, nml B12
macro anemia 2/2 B12 def: labs high MCV, aniso, poik, macro-ovalocytes, hypersegs; high LDH & indirect bili; low B12, low retic, high methylmalonic acid
G6PD def inc retic & ind bili; bite cells & Heinz bodies
CRAG = cryptococcal Ag assay
Hemolytic anemia lab findings Low haptoglobin; high LDH (microangiopathic hemolysis), high indirect bili (not >4-5mg/dL unless underlying liver dz); high retic with low-normal H&H; hemoglobinuria; stable or falling Hgb
Absolute Neutrophil count formula WBC x (% segs + % bands) = ANC
Neg Coombs hereditary spherocytosis
Pos Coombs AIHA, cold agglutinin
HIT labs Plt drop 4-10 d post heparin; 50% of plt baseline; coags normal; confirm w/Serotonin Release Assay
PT measures: extrinsic (FVII) & common pathways (Factor 1,2,5,10) (exogenous TF is added to initiate clotting)
aPTT measures: intrinsic (factors 12,11,9,8) & common pathways (1,2,5,10)
Cause of prolonged PT: Def. in FVII and Common Pathway Factors (FX, FV, FII, Fibrinogen); Liver Dz; Warfarin tx; Vit K Def; Inhibitor to FVIIa (rare)
Common pathway deficiencies will prolong: PT & aPTT
von W Disease usually presents with PT and aPTT that are: Normal
Anti-Phospholipid Syndrome: Labs prolonged aPTT (b/c in vitro fx of the Ab on aPTT); mixing study fails to normalize; confirmatory tests required to make the diagnosis
Confirm HIT with: Serotonin Release Assay
Unlike PTT, PT tests for factor 7
PT monitors: Coumadin; common pathway (1,2, 5, 10); F7
PT/PTT ref ranges PT = 11-13; PTT = 26-36
PTT monitors: Heparin; intrinsic (12, 11, 9, 8); common pathway (1,2, 5, 10)
Formula: corrected retic % retic x HCT/45% = absolute % retics
Hallmark of Waldenstrom: Monoclonal IgM spike in SPEP
Waldenstrom is differentiated from MGUS by: Presence of bone marrow infiltration
Pancytopenia seen in: ALL, AML, hairy cell
Giant plts & teardrop poik Myelofibrosis
Dohle bodies blue patch near edge; PMN; infxn
Toxic gran purple/blue-black; PMN; severe infxn/toxic
Hyperseg: 6 or more; PMN; megaloblastic anemia, B12-folate def
Causes of prolonged aPTT: Def of intrinsic (FXI, FVIII, FIX ) & common pathway factors; Heparin & DTI tx; Inhibitors to coag factors
Prolonged aPTT; doesn't correct w/mixing study FVIII inhibitor
PT is sensitive to (1) & normal range is (2) (1) FVII ; (2) 9.5-13.1
aPTT measures: intrinsic (factors 12,11,9,8) & common pathways (1,2,5,10)
aPTT normal range 24.1-32.3 sec (uses neg charged particles to initiate)
Very rare causes of prolonged PT FVII def; FVIIa inhib
DIC labs: 1st PT prolonged 1st (2/2 short FVII half-life), then long aPTT. Low factor II, V, VII, VIII, IX, X) & fibrinogen & AT & platelets. Anemia High D-Dimer (more specific than FSP). Schistocytes; likely toxic granulation.
Normal bleeding time is < 8 min
Single best indication of functional platelet deficiency Bleeding time
When is bleeding time is prolonged? Platelets <100,000. Abnormal platelet function. Drugs (eg, clopidogrel)
Heparin tx PTT range 50-70 seconds
Negative Coombs hereditary spherocytosis
Positive Coombs AIHA, cold agglutinin
Heinz bodies Hemolytic anemias (G6PD)
Low retic is found in: hypoproliferative anemia; B12; PRCA; aplastic anemia
Defintion of neutropenia PMN <1500 (AA may have 1200 normal)
Absolute Neutrophil count formula WBC x (% segs + % bands) = ANC
Reticulocytosis may reflect: Hemolytic anemias. Elevated retic indicates increased RBC production
PNH labs Flow cytometry: absence of CD59 Ab. Normocytic; hemoglobinuria
Sickle cell labs Very low Hgb (7-10). sickled cells: 5-50% of RBCs. Reticulocytosis. NRBCs. Leukocytosis, thrombocytosis, high indirect bilirubin
H&H normal ranges RBC: M 4.4-5.9, F 3.8-5.2. Hgb: M 13.3-17.7, F 11.7-15.7. Hct: M 40-52%, F 35-47%
Gold standard test to measure Hct RBC mass: nuclear med test measuring mL RBCs per kg body wt (usually reserved to evaluate polycythemia
Normal retic range 0.5-1.5%
Lead poisoning labs Micro/hypo, basophilic stippling. ringed sideroblasts. Increased Fe, normal TIBC, increased transferring & ferritin. Lead lines in xrays of long bones. Blood lead level >10 in kids
Pernicious anemia labs Serum IF (intrinsic factor) antibodies, parietal cell antibodies, high serum gastrin levels, high MMA and homocysteine. pos Schilling test
Anemia of chronic disease labs N/N (possibly mildly micro/hypo). Normal-high ferritin. Low Fe and TIBC.
Transferrin saturation calculation Serum iron / TIBC
ITP labs Isolated thrombocytopenia +/- megakaryocytes in BM. Acute form <20,000. Chronic form 30,000-80,000. Coags normal. Platelet clumping on smear suggests pseudothrombocytopenia
Hemophilia A & B labs Decreased level of FVIII or FIX. Increased PTT; normal PT, bleeding time, & fibrinogen.
Hemophilia A & B: mixing study results Mixing normal plasma with Hemophilia pt plasma -> normal PTT
von Willebrand labs BT >8 min. Low factor VIII level. High PTT. Platelet aggregation abnormal with ristocetin. Low vW antigen (VWF:Ag); Low levels of vW Activity (VWF:RCo). Multimers are decreased
Liver dz coagulopathy labs Prolonged PT>PTT. Long PTT in advanced dz. Mixing study corrects. No response to Vitamin K. low fibrinogen. Target cells & macrocytes on PBS.
Lupus anticoagulant labs Immunoglobulin in pts with / without SLE. Increases risk of VTE & spontaneous abortion. High PTT. Mixing study does not completely correct.
Beta thalassemia labs Beta major: Hgb A2 and Hgb F. Beta minor: Hgb A2
Created by: Abarnard