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TM 6-10
| Question | Answer |
|---|---|
| The maximum allowable annual loss of RBCs for a apheresis platelet donor is ___ ml | 1400 |
| The maximum allowable annual loss of plasma for a apheresis platelet donor is ___ ml | 12000ml if donor weighs < or = 175; 14,400 if donor >175pounds |
| minimum hemoglobin for double RBC procedure | 13.3 g/dL or 40% HCT |
| minimum heights and weights for double RBC donors | men = 5'1" and 130 pounds; women =5'5" and 155 pounds |
| expected iron loss in a whole blood donation | 200mg to 250 mg depending onHCT |
| rate of vasovagal reactions for whole blood donation | 5.3% |
| Who has more vasovagal reactions: apheresis donors or whole blood donors? | whole blood donors |
| How long after a whole blood donation until a donor can donate platelets? | 72 hours |
| How many platelet donations can a donor give in a year? | 24 |
| How many platelet donations can a donor give in a week? | 2 |
| How long does a platelet donor have to wait until donating platelets again? | 2 days |
| If RBC losses exceed 100 ml, a platelet donor must wait this period before donating again | 56 days |
| Is a platelet count required before first plateletpheresis donation? | No |
| RBC loss must be less than __ml in serial plasmapheresis donors | 25ml |
| How often are serial (frequent)source plasma donors tested for SPEP and total protein? | at the initial plasmapheresis and every months |
| What frequency can RBCs be given in a case of exceptional medical need? | every 3 days with medical director approval as long as hgb/hct meet requirements (13 g/dL for male; 12.5 g/dL for female |
| Ready source of platelets in NAIT | maternal |
| Most common specificity of alloantibody in whites with NAIT | HPA-1a |
| What are the additional requirements for pretransfusion handling when using maternal platelets for NAIT? | irradiation and washing |
| The most common cause of transfusion associated anaphylaxis in the US. | reactions related to antibodies to IgA in IgA deficiency |
| Who has a higher rate of viral marker positivity: A. Directed blood donor B. Volunteer blood donor | A. Directed blood donor: because most are first time donors |
| Minimum hemoglobin required for autologous blood donation | 11g/dL |
| Minimal interval between autologous whole donations | 72 hours |
| How many blood donors experience a reaction? | 2 to 5% |
| Most common blood donor reaction | vasovagal reaction |
| Describe the demographics of donors most likely to have a reaction | young (<20), female, first time donor or prior adverse reaction |
| Incidence of nerve injury from blood donation phlebotomy | 1 in 5000 |
| Incidence of vasovagal reactions from blood donation | 1 in 40 |
| Incidence of arterial puncture from blood donation phlebotomy | 1 in 10,000 |
| How is arterial puncture recognized? | bag fills fast (<4minutes), blood is bright red |
| Which donors have a higher rate of vasovagal reactions: A. plasmapheresis B. whole blood | B. whole blood |
| Why do apheresis donors get hypocalcemic? | use of citrate as an anticoagulant |
| Symptoms of hypocalcemia | perioral tingling, peripheral parethesias |
| Treatment of hypocalcemia | oral calcium, slow rate, end procedure |
| Pheresis donors may be sensitive to this sterilizer which can cause allergic/anaphylactic reactions | ethylene oxide |
| specific gravity of RBCs | 1.08-1.09 |
| specific gravity of plasma | 1.03-1.04 |
| specific gravity of platelets | 1.023 |
| Storage temperature for RBCs | 1-6 degrees C |
| Shelf life of RBCs stored in CPD | 21 days |
| Shelf life of RBCs stored in CP2D | 21 days |
| Shelf life of RBCs stored in CPD1a | 35 days |
| Shelf life of RBCs stored in AS-1 | 42 days |
| Shelf life of RBCs stored in AS-3 | 42 days |
| which unit of packed RBCs has a higher hematocrit: A. CPD B. AS-3 | A. CPD is 80% HCT B. AS-3 is 60% HCT |
| Storage temperature for frozen RBCs | minus 65 degrees C |
| For RBC units, this process is used to minimize the risk of recurrence of severe allergic/anaphylactic reactions | washing |
| Name 3 risk that leukoreduction of RBC units addresses | 1. FNHTR 2. TA-CMV 3. HLA alloimmunization |
| For RBC units, this process is used to minimize the risk of TA-GVHD | irradiation |
| To make FFP, when does the separation of plasma and RBCs have to occur? | within 8 hours of collection |
| Storage temperature for FFP | minus 18 for 1 year (with FDA approval can store FFP for 7 years at minus 65) |
| Temperature of water bath used to thaw out FFP | 30-37 degrees C |
| What is thawed plasma? | After thawing FFP has a shelf life of 24 hours at 1-6 degrees C. When that time elapses it becomes thawed plasma which is good up to 5 days |
| What is the primary indication for cryoprecipitate? | replacement of fibrinogen |
| What is the volume of a unit of cryo? | 15 ml |
| What is the process for manufacturing cryo? | thaw FFP at 1-6 C. Collect and freeze precipitate. |
| What is the amount of fibrinogen in a bag of cryo? | 150 mg per unit |
| What is the amount of factor VIII in a bag of cryo? | 80IU per unit |
| What proteins are in a bag of cryo? | factor VIII, fibrinogen, fibronection, factor XIII, and vWF |
| Usual adult does of cryo | 8-10 bags |
| Storage requirements for cryo | minus 18C for 1 year |
| After thawing, cryo is stored at this temperature for how long? | 20-24 C; 6 hours if closed system. 4 hours if open system. |
| What condition is cryo reduced plasma, CPP used for? | TTP |
| How many platelets must be in a unit of whole blood derived platelets? | >5x 10(10) |
| How many platelets must be in a unit of apheresis platelets? | >3x10(11) in 75% of products tested |
| Storage requirements for platelets | 20-24C; 5 days; gentle agitation |
| Storage requirements for granulocytes | 20-24C; 24 hours |
| This is the most immunogenic of the RBC antigens | D |
| Can you use RBCs from donors whose Antibody screen is positive? | Yes, IF recipient is antigen negative or if unit is washed before transfusing. |
| Alloimmunization occurs in this % of patients who are transfused a unit of RBCs | 2-6% for most; as high as 36% for chronically transfused Sickle cell disease patients |
Created by:
jfshikle
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