Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Renal Phys 4
WVSOM -- Renal Phys -- measuring clearance and transport
| Question | Answer |
|---|---|
| What is clearance? | volume of plasma cleared of a substance per unit time |
| What is the equation for clearance? | Ux/Px X V |
| What do you know if you know GFR and clearance? | any difference between GFR and clearance of X tells you something about net secretion or reabsorption |
| What is the units of clearance? | ml/min |
| If urine Na is 810 mEq/L, plasma Na is 138 mEq/L and urin flow is 1 ml/min what is the clearance of Na? | (810/138) x 1 = 5.87 ml/min |
| If substance X is filtered and completely reabsorbed what is the clearance of X? | ZERO |
| What makes inulin a good indicator for GFR? | it is freely filtered by the glomerulus and it is not reabsorbed or secreted. |
| Why are calcium, phosphate and magnesium not freely filtered? | they are bound to protein |
| What is freely filtered mean/ | concentration of X in bowman’s capsule is the same as that in blood plasma |
| Why is creatine used to estimate GFR? | has properties like inulin and is exported to the blood continuously by skeletal muscle. It is freely filtered and not reabsorbed with only a small amount secreted so the clearance is only slightly higher than GFR |
| Creatinine clearance is mostly _________________ of urine flow. | independant |
| When will the clearance of creatine be off? | if the patient has a non-steady state as in hyperthermia or other muscle wasting conditions or damage. |
| What is normal plasma value of creatinine? | 1mg/dl |
| What kind of relationship between plasma creatinine and GFR? | inverse |
| If GFR dramatically decreases, plasma creatinine will? | increase |
| What is BUN? | Blood Urea Nitrogen |
| What does renal urea reabsorption depend on? | urine flow. Low flow, more urea reabsorbed |
| In renal disease, low GFR leads to…. | low urine flow, increase in urea retention nd increased BUN |
| What happens with volume depletion? | urine flow BIG decline, urea excretion drops even out of proportion to the fall in GFR, High BUN, BUN/Creatinine ratio increases |
| Why does BUN/Creatinine ratio increase with volume depletion? | urea excretion is flow dependant but creatinine is not |
| What confirms dehydration? | BUN |
| Filtered load = | GFR x Px |
| Excretion rate = | Ux X V |
| Amount excreted = | amount filtered – amount reabsorbed + amount secreted |
| Filtration Fraction = | GFR/RPF |
| Increased FF means what in regards to bowman’s capsule? | more fluid into bowman’s capsule |
| Reabsorption rate = | filtered load – excretion rate |
| Secretion rate = | excretion rate – filtered load |
| Clearance = | Ux/Px X V |
| GFR in regards to inulin clearance. | equal to each other |
| Clearance of PAH is what compared to GFR? | greater |
| GFR = | Kf X NFP |
| NFP = | Pgc - ∏gc – Pbc + ∏bc |
Created by:
tjamrose
Popular Physiology sets