Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Transfusion rxns
adverse effects of blood transfusion
| Question | Answer |
|---|---|
| Most common cause of ABO-incompatibility-induced acute hemolysis | patient misidentification |
| Drug-induced hemolysis is commonly caused by these drugs | cefotetan, ceftriaxone, and NSAIDs |
| Mechanical hemolysis can occur in these settings | artificial heart valves, extracorporeal circulation, transfusion through a small bore catheter under high pressure |
| What is done to mitigate the risk of a febrile non-hemolytic transfusion reaction (FNHTR)? | leukoreduction |
| These common conditions are more common in patients who have allergic transfusion reactions | hay fever and food allergy |
| What should you do if a patient with a history of anaphylactic transfusion reactions needs a RBC transfusion? | wash the cells |
| second most common cause of transfusion-associated fatalities | TACO |
| Definition of TRALI | acute lung injury with hypoxemia within 6 hours of transfusion. No prior risk factors for acute lung injury. |
| The most common cause of TRALI | infusion of HLA antibodies that opsonize WBCs and get stuck in pulmonary capillaries. Contents of neutrophils released damaging lung. |
| Typical donor implicated in a TRALI reaction | multiparous female |
| Mortality rate for TRALI | 10% |
| How long does TRALI usually last? | 48 to 72 hours |
| Most common cause of transfusion-related mortality | TRALI (TACO in 2021) |
| What causes a "hypotensive transfusion reaction?" | generation of bradykinin from activation of the kinin pathway caused by contact of plasma with artificial surfaces. |
| Most common bacteria in a prospectively cultured blood unit | Skin flora (staphylococcus and propionibacteria) |
| These bacteria which can grow at low temperature may proliferate in RBC units | yersinia and pseudomonas |
| Why should calcium not be added to a unit of blood? | it could reverse the anticoagulant effect of citrate |
| This condition is characterized by onset of profound thrombocytopenia 1 to 3 weeks after transfusion | post-transfusion purpura |
| what blood products have been implicated in post-transfusion purpura? | all blood products |
| What is the pathophysiology of post-transfusion purpura? | antibody to platelet antigen (HPA-1a) |
| What is the treatment and clinical course of post-transfusion purpura? | resolves without treatment in 3 weeks if mild. IVIG if bad. |
| What is the role of platelet transfusion in post-transfusion purpura? | emergency only. no role for prophylaxis |
| How do you prevent transfusion associated graft-versus-host disease? | irradiation of cellular blood products |
| This is the most common cause of post-transfusion hepatitis | Hepatitis B |
| Current estimated window period for HIV | 9 days |
| How do you reduce transfusion associated CMV? | leukoreduction and/or seronegative for CMV units |
| These diseases are associated with HTLV-I | 1. adult T-cell leukemia-lymphoma 2. HTLV-associated myelopathy |
| The most frequently implicated malaria species in a transfusion associated case of malaria | plasmodium falciparum |
Created by:
jfshikle
Popular Laboratory Science sets