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Stack #200476
| Question | Answer |
|---|---|
| name the 2 respiratory GNB | haemophilus, moraxella |
| name the 3 enteric GNB | E coli, proteus, klebsiela |
| where are enterics GBB's found commonly | GI/GU |
| name the 5 nosocomial GNB (space) | serratin, pseudomonus, acinebactor, citrobacter, enterobacter |
| treatment for the respiratory GNB (haemophilus, moraxella) | augmentin, 2nd or 3rd gen ceph, doxy, bactrim, FQ |
| treatment for the enterics (ecoli, proteus, klebsiella) | 2nd or 3rd gen ceph, the penicillins with beta lactamase inh, aztreonen (beta lactam), FQ, carbapenem (beta lactam) |
| nociocomal is the but for what sort of infections | pneumonia, UTI, surgical site infections, diabetic foot infections |
| Serratia (nociocomal)have resistance to what drugs | 1st gen ceph and ampicillin |
| where is the nociocomal but pseudomonas typically found | sink in bathroom, tennis shoes, ICU, hot tubs |
| pseudomonas (nociocomal) infects when/how? | puncture wounds, healthcare associated, otitus |
| treatment for pseudomonas | piperacillin, ceftazidine and cefempine, astreonam, imipenem, amikacin, cipro |
| Enterobacter (nociocomal) treatments | carbepenem, cefepine, FQ, tigecycline |
| acinetobacter (nociocomal) problems and where is it found? | UTI, pneumonia....soil, water, 25% of healthy adults |
| which bug is associated with "inducible resistance" ? | enterobacter |
| what type of bacteria is bacteroides fragilis? | anaerobe |
| where is bacteroids fragilis commonly found? | GI tract |
| bacteroids fragilis is usually a "co-pathogen" | yes |
| 3 treatments for B fragilis that are 100% effective? others? | metronidazole, carbepenems, unasyn/zosyn..clinda, cefxitin/cefotetean, tigecyclin, moxifloxacin |
| what are 2 other anaerobes? | peptostreptococcus, mouth flora |
| treatment for the "other" 2 anearobes | PCN, amox, cephalexin, clindamycin, moxifloxacin, cefoxitin |
| name the 3 gram positive cocci? | staph, strep, entero |
| name the different gram positive bacilli?? | ? |
| what is the test called that differentiates staph aureus from the other ones? what does positive mean? | coagulase test...if positive means aureus |
| what is staph aureus the major cause of? | skin/soft tissue infection, nosocomial bacteremia, nosocomial pneumonia, bone/joint infections, endocarditis |
| what is the mech of resistance for MSSA? MRSA? | MSSA: beta lactamase...MRSA: change binding sites (mecA, MLS (ribosome 50 subunit change), aminoglycoside modifying enzyme, altered target on DNA gyrase (FLQ), increased efflus (tetracyclines) |
| what is the D test? | detects for the MLS gene...dont use if there is a D around the clinda |
| MSSA treatment? | oxacillin (diclox, nafcicillin), cefazolin (1st gen), clinda, vanco |
| why isnt methacyllin used often? | side effects..interstitial nephritis for example |
| MRSA treatment | vanco (1st line), linezolid, daptomycin, tigecycline |
| side effects of linezolid | MAO inhibitor, bone marrow suppression, thrombocytopenia, anemia, lactic acidosis |
| what is PVL? | leukocyte and proinflammatory toxin, increases virulence in CA-MRSA |
| treating CA-MRSA | vanco (MIC is creeping), linezolid, daptomycin...tmp/smx, doxy, clinda (resistance growing) |
| where is coagulase negative staph found? | skin |
| what is it a common pathogen for? | prosthetic material |
| coagulase negative staph treatment | mild/mod: doxy, bactrim, linazolid.....moder/severe: vanco |
| strep pneumoniae is found where? | upper respiratory |
| Strep pneumoniae is common pathogen for? | upper resp infection, sinusitus, acute otitis media, community acquired pneumonia, meningitis, bacteremia (bacteria in the blood) |
| treatment for Strep pneumoniae? | mod/svere: pcn, cefriaxone, resp FQN (levo and moxy), vanco |
| where is "other strep" found? | mouth, skin, GI tract, female GU tract |
| what is "other strep" a common pathogen for? | dental infection, endocarditis, cellulitis, peritonitis, pharyngitis, neonatal infxn |
| treatment for "other strep" | mod/severe: pcn/ampicill/amox/nafcill, cephalosporin, vanco |
| 2 most common enterococci? | E faecalis (80%), E faecium |
| where is enterococci commonly found? | GI/GU tract |
| what is enterococci a common pathogen for | endocarditis, UTI, bacteremia, intra-abdominal infection |
| treat of faecalis enterococcus | mod/severe: ampicillin IV(gold standard), pcn/peperacillin, imipenem, vanco (for severe), LZD, daptomycin |
| E faecium treatment | mod/severe: linezolid, daptomycin, tigecycline |