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name the 2 respiratory GNB haemophilus, moraxella
name the 3 enteric GNB E coli, proteus, klebsiela
where are enterics GBB's found commonly GI/GU
name the 5 nosocomial GNB (space) serratin, pseudomonus, acinebactor, citrobacter, enterobacter
treatment for the respiratory GNB (haemophilus, moraxella) augmentin, 2nd or 3rd gen ceph, doxy, bactrim, FQ
treatment for the enterics (ecoli, proteus, klebsiella) 2nd or 3rd gen ceph, the penicillins with beta lactamase inh, aztreonen (beta lactam), FQ, carbapenem (beta lactam)
nociocomal is the but for what sort of infections pneumonia, UTI, surgical site infections, diabetic foot infections
Serratia (nociocomal)have resistance to what drugs 1st gen ceph and ampicillin
where is the nociocomal but pseudomonas typically found sink in bathroom, tennis shoes, ICU, hot tubs
pseudomonas (nociocomal) infects when/how? puncture wounds, healthcare associated, otitus
treatment for pseudomonas piperacillin, ceftazidine and cefempine, astreonam, imipenem, amikacin, cipro
Enterobacter (nociocomal) treatments carbepenem, cefepine, FQ, tigecycline
acinetobacter (nociocomal) problems and where is it found? UTI, pneumonia....soil, water, 25% of healthy adults
which bug is associated with "inducible resistance" ? enterobacter
what type of bacteria is bacteroides fragilis? anaerobe
where is bacteroids fragilis commonly found? GI tract
bacteroids fragilis is usually a "co-pathogen" yes
3 treatments for B fragilis that are 100% effective? others? metronidazole, carbepenems, unasyn/zosyn..clinda, cefxitin/cefotetean, tigecyclin, moxifloxacin
what are 2 other anaerobes? peptostreptococcus, mouth flora
treatment for the "other" 2 anearobes PCN, amox, cephalexin, clindamycin, moxifloxacin, cefoxitin
name the 3 gram positive cocci? staph, strep, entero
name the different gram positive bacilli?? ?
what is the test called that differentiates staph aureus from the other ones? what does positive mean? coagulase test...if positive means aureus
what is staph aureus the major cause of? skin/soft tissue infection, nosocomial bacteremia, nosocomial pneumonia, bone/joint infections, endocarditis
what is the mech of resistance for MSSA? MRSA? MSSA: beta lactamase...MRSA: change binding sites (mecA, MLS (ribosome 50 subunit change), aminoglycoside modifying enzyme, altered target on DNA gyrase (FLQ), increased efflus (tetracyclines)
what is the D test? detects for the MLS gene...dont use if there is a D around the clinda
MSSA treatment? oxacillin (diclox, nafcicillin), cefazolin (1st gen), clinda, vanco
why isnt methacyllin used often? side effects..interstitial nephritis for example
MRSA treatment vanco (1st line), linezolid, daptomycin, tigecycline
side effects of linezolid MAO inhibitor, bone marrow suppression, thrombocytopenia, anemia, lactic acidosis
what is PVL? leukocyte and proinflammatory toxin, increases virulence in CA-MRSA
treating CA-MRSA vanco (MIC is creeping), linezolid, daptomycin...tmp/smx, doxy, clinda (resistance growing)
where is coagulase negative staph found? skin
what is it a common pathogen for? prosthetic material
coagulase negative staph treatment mild/mod: doxy, bactrim, linazolid.....moder/severe: vanco
strep pneumoniae is found where? upper respiratory
Strep pneumoniae is common pathogen for? upper resp infection, sinusitus, acute otitis media, community acquired pneumonia, meningitis, bacteremia (bacteria in the blood)
treatment for Strep pneumoniae? mod/svere: pcn, cefriaxone, resp FQN (levo and moxy), vanco
where is "other strep" found? mouth, skin, GI tract, female GU tract
what is "other strep" a common pathogen for? dental infection, endocarditis, cellulitis, peritonitis, pharyngitis, neonatal infxn
treatment for "other strep" mod/severe: pcn/ampicill/amox/nafcill, cephalosporin, vanco
2 most common enterococci? E faecalis (80%), E faecium
where is enterococci commonly found? GI/GU tract
what is enterococci a common pathogen for endocarditis, UTI, bacteremia, intra-abdominal infection
treat of faecalis enterococcus mod/severe: ampicillin IV(gold standard), pcn/peperacillin, imipenem, vanco (for severe), LZD, daptomycin
E faecium treatment mod/severe: linezolid, daptomycin, tigecycline
Created by: tayl1336
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