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Glycophorins A and B carry the MNS antigens, and they may also serve as receptors for cytokines and pathogens, including the malaria parasite, Plasmodium falciparum.
Which chromosome contains the MNS antigen gene? chromosome 4
Frequency of MNS antigens (%) M: 78% Caucasians, 74% Blacks N: 72% Caucasians, 75% Blacks S: 55% Caucasians, 31% Blacks s: 89% Caucasians, 93% Blacks
Frequency of MNS phenotypes (%) M+N+S-s+: 22% whites, 33% Blacks M+N+S+s+: 24% Caucasians, 13% Blacks M-N+S-s+: 15% Caucasians, 19% Blacks M+N-S+s+: 14% Caucasians, 7% Blacks M+N-S-s+: 8% Caucasians, 16% Blacks M-N+S+s+: 6% Caucasians, 5% Blacks M+N-S+s: 6% Caucasians, 2% Blacks
Function of MNS antigens Glycophorins A and B may serve as receptors for cytokines, bacteria, and viruses, but the lack of the glycophorins does not result in disease, indicating that their function is not physiologically significant
Individuals who have rare blood types in which either the glycophorin A or B is absent, e.g., phenotypes En(a-) and S-s-U-, have RBCs that are resistant to invasion by these organisms. Plasmodium
Are Anti-M and anti-N considered to be a cause of transfusion reactions Anti-M and anti-N are not considered to be a cause of transfusion reactions, although rare cases of delayed transfusion reactions have occurred as a result of anti-M. Anti-M is fairly common; mostly naturally occurring because it is frequently found in ch
Describe complexity of glycophorins A and B Glycophorins A and B are single-pass, transmembrane proteins. Glycophorin A contains abundant sialic acid, which contributes to the negative surface charge of the RBC membrane.
Created by: jfshikle