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What is the function of the Kidd glycoprotein? The Kidd (JK) glycoprotein is the red blood cell (RBC) urea transporter
This RBC antigen situated in the membrane rapidly transports urea into and out of RBCs, maintaining the osmotic stability and shape of the RBC in the process. Kidd
Kidd glycoprotein is also expressed in this organ kidney, where it enables the kidney to build up a high concentration of urea which is needed for the kidney to produce concentrated urine.
Describe the clinical features of People who do not produce the Kidd glycoprotein not able to maximally concentrate urine, but despite this, they are healthy and their RBCs have a normal shape and lifespan.
Do Kidd antibodies cause HTR and/or HDN? significant cause of delayed hemolytic transfusion reactions. Anti-Kidd antibodies are also a cause of hemolytic disease of the newborn (HDN), severity tends to be mild in nature.
what chromosome is the Kidd glycoprotein gene on? Located on chromosome 18
Frequency of Kidd antigens Jka: 77% Caucasians, 92% Blacks, and 73% Asians Jkb: 74% Caucasians, 49% Blacks, and 76% Asians Jk3: 100% in most populations, >99% in Polynesians
Frequency of Kidd phenotypes Jk(a+b+): 50% Caucasians, 41% Blacks, 49% Asians Jk(a+b-): 26% Caucasians, 51% Blacks, 23% Asians Jk(a-b+): 23% Caucasians, 8% Blacks, 27% Asians JK(a-b-): Rare in most populations, found in 0.9% Polynesians
Isotype of Kidd antibodies IgG and IgM IgG is more common
Do Kidd antibodies bind complement ? Capable of hemolysis Can bind complement
Are Kidd antibodies associated with Hemolytic transfusion reactions? common cause of delayed hemolytic transfusion reactions. Anti-Jka and anti-Jkb are dangerous antibodies because they can be difficult to detect in routine blood cross-matches.
Are Kidd antibodies associated with Hemolytic disease of the newborn Yes—typically mild disease
estimated that ___%of DHTRs are caused by anti-Jka It has been estimated that over one-third of DHTRs are caused by anti-Jka
Created by: jfshikle