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Bio Phys
USCSOM: BioPhysiology
Question | Answer |
---|---|
What is what percent of body mass? | 60% |
What is the lipid water partition coefficient? | [lipid]/[water] |
What is the nernst equation? | 60/Z log [Xo]/[Xi] |
What is the equilibrium potential for K+? | -94mV |
What is the equilibrium potential for Na+? | +69mV |
What is an osmole? | term used to express the concentration of a solution in terms of the number of particles |
What is osmolarity? | concentration of osmoles/L of water |
What is the estimated osmolality of blood? | 290 mOsm/kg |
Describe secondary active transport. | 1 solute against concentration gradietn, 1 solute with conc. gradient |
What is hemocrit? | RBC Vol / Blood Vol |
What is the equilibrium potential for Cl-? | -76mV |
What is the equilibrium potential for Ca2+? | 125mV |
What toxin blocks Na+ conductance? | TTX or STX |
What keeps Na+ channels open? | CTX or BTX |
What toxin blocks K+ channels? | 4-AP and 3,4-DAP |
What toxin blocks Ca2+ channels? | marine cone snail, funnel-web spider |
What toxin causes opening of Ca channels? | latrotoxin |
What is required for NMDA receptor activation? | Gultamate/Aspartate, -70mV to remove Mg |
Describe MS. | Demylenating disease of the CNS, hyper-reflexia |
Describe GBS.. | Demylenation of peripheral neurons, hypo-reflexia |
What are the 2 presynaptic membrane proteins? | Syntaxin and SNAP-25 |
What are the docking proteins? | Syntaxin, SNAP-25, synaptobrevin |
What presynaptic vessicle protein binds Ca? | Synaptotagmin |
What toxin proteases act on docking proteins to prevent neurotransmitter release? | tetanus and botulinum (Clostridium bacteria) |
What is EPSP? | excitatory post-synaptic potential |
What is IPSP? | inhibitory post-synaptic potential |
What type of receptors are EPSP? | nicotinic, NMDA, non-MDA |
What type of receptors are IPSP? | GABA, Glycine (Cl) |
What happens in myasthenia gravis? | antibodies block nicotinic receptors, Na channels |
What happens in Lambert-Eaton Syndrome? | antibodies block presynaptic Ca channels, reducing amount of Ach released |
What are the metabotropic receptors? | muscarinic M1-M5; adrenergic |
What is muscular response to hypokalemia? | hyporeflexia |
What is muscular response to hyperkalemia? | hyperreflexia |
What is muscular response to hypocalcemia? | hyperreflexia |
What is muscular response to hypercalcemia? | hyporeflexia |
What is muscular response to hyponatremia? | none; cannot diffuse through membrane |
What is muscular response to hypernatremia? | none; cannot diffuse through membrane |