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Bio Phys

USCSOM: BioPhysiology

What is what percent of body mass? 60%
What is the lipid water partition coefficient? [lipid]/[water]
What is the nernst equation? 60/Z log [Xo]/[Xi]
What is the equilibrium potential for K+? -94mV
What is the equilibrium potential for Na+? +69mV
What is an osmole? term used to express the concentration of a solution in terms of the number of particles
What is osmolarity? concentration of osmoles/L of water
What is the estimated osmolality of blood? 290 mOsm/kg
Describe secondary active transport. 1 solute against concentration gradietn, 1 solute with conc. gradient
What is hemocrit? RBC Vol / Blood Vol
What is the equilibrium potential for Cl-? -76mV
What is the equilibrium potential for Ca2+? 125mV
What toxin blocks Na+ conductance? TTX or STX
What keeps Na+ channels open? CTX or BTX
What toxin blocks K+ channels? 4-AP and 3,4-DAP
What toxin blocks Ca2+ channels? marine cone snail, funnel-web spider
What toxin causes opening of Ca channels? latrotoxin
What is required for NMDA receptor activation? Gultamate/Aspartate, -70mV to remove Mg
Describe MS. Demylenating disease of the CNS, hyper-reflexia
Describe GBS.. Demylenation of peripheral neurons, hypo-reflexia
What are the 2 presynaptic membrane proteins? Syntaxin and SNAP-25
What are the docking proteins? Syntaxin, SNAP-25, synaptobrevin
What presynaptic vessicle protein binds Ca? Synaptotagmin
What toxin proteases act on docking proteins to prevent neurotransmitter release? tetanus and botulinum (Clostridium bacteria)
What is EPSP? excitatory post-synaptic potential
What is IPSP? inhibitory post-synaptic potential
What type of receptors are EPSP? nicotinic, NMDA, non-MDA
What type of receptors are IPSP? GABA, Glycine (Cl)
What happens in myasthenia gravis? antibodies block nicotinic receptors, Na channels
What happens in Lambert-Eaton Syndrome? antibodies block presynaptic Ca channels, reducing amount of Ach released
What are the metabotropic receptors? muscarinic M1-M5; adrenergic
What is muscular response to hypokalemia? hyporeflexia
What is muscular response to hyperkalemia? hyperreflexia
What is muscular response to hypocalcemia? hyperreflexia
What is muscular response to hypercalcemia? hyporeflexia
What is muscular response to hyponatremia? none; cannot diffuse through membrane
What is muscular response to hypernatremia? none; cannot diffuse through membrane
Created by: jlellerm



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