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BB guy 1

bb guy section 1 notes from start through ABO

Low Ionic Strength Saline (LISS) enhances these antibodies cold antibodies and autoantibodies
Polyethylene glycol (PEG) enhances these antibodies warm antibodies and autoantibodies
Immediate spin (IS) phase antibodies are usually this isotype IgM
This test detects RBCs coated with IgG +/– complement in vivo DAT (Direct Coombs)
Explain the term "dosage" in regards to RBC antigens Some antibodies react more strongly with RBCs that have double-dose (“homozygous”) antigen expression
enzymes like papain and ficin decrease the reactions associated with these RBC antigens MNS System Duffy System
enzymes like papain and ficin increase the reactions associated with these RBC antigens UCLA Pneumonic: Lewis P Is A Rhotten Kidd" ABO-related: ABO, H Systems, Lewis System, I System, P System Rh System Kidd System
The effect of enzymes on the Kell blood group antigens when performing antibody identification None
substance used to neutralize ABO antibodies ABO: Saliva (secretor)
substance used to neutralize Lewis antibodies Saliva (secretor for Leb)
substance used to neutralize P1 antibodies Hydatid cyst fluid Pigeon/dove egg white
substance used to neutralize Sda antibodies Human urine
substance used to neutralize Chido antibodies Serum (complement)
substance used to neutralize Rodgers antibodies Serum (complement)
Specificity of the lectin Dolichos biflorus A1
Specificity of the lectin Ulex europaeus H (absent in Bombay phenotype)
Specificity of the lectin Vicia graminea N
Specificity of the lectin Arachis hypogea T
Specificity of the lectin Glycine max T, Tn
Specificity of the lectin Salvia Tn
Most significant antibodies are this isotype and react best at this temperature IgG and "warm reactive"
Most insignificant antibodies are this isotype and react best at this temperature IgM and “cold reactive
Se (“secretor”) gene codes for this enzyme FUT2; “fucosyltransferase” FUT enzyme adds fucose to type 1 chains at terminal galactose; product is type 1 H antigen
This gene is required to make A or B antigens in secretions Se gene
Frequency of Se gene 80%
this antigen is required before A and/or B can be made on RBCs H type 2 H on RBCs or in secretions, type 1 H
This sugar is added to a type 2 H antigen chain to make Group A RBCs N-acetylgalactosamine
This sugar is added to a type 2 H antigen chain to make Group B RBCs Galactose
ABO antigens begin to appear on fetal RBCs at ___ weeks gestation 6
ABO antigens are also present on these tissues platelets, endothelium, kidney, heart, lung, bowel, pancreas tissue
Isotype of antibodies to ABO antigens in group O people IgG
Most common ABO group O
Why is HDFN not severe in type O mom with type A baby? Weak fetal ABH expression, soluble ABH antigens (neutralize antibodies)
amount of A antigen present on A1 RBCs compared to A2 RBCs 5x
The cause of acquired B phenotype Bacterial enzymes (deacetylase) deacetylate group A GalNAc; remaining galactosamine looks like B
Conditions associated with acquired B phenotype Colon cancer, intestinal obstruction, gram-negative sepsis
Naturally occurring antibodies in the Bombay phenotype anti-A, ant-B, antiAB, anti-H Total lack of H, A and B antigens due to lack of H and Se genes (genotype: hh, sese)
Para-Bombay phenotype differs from Bombay phenotype because of this have at least one Se gene RBCs may be Bombay-like, but may also show free or RBC A or B antigens (unless group O) Antibody profile is same as Bombay
Created by: jfshikle