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Hematology 1
Test 2 - Chapters 5,6,10
| Question | Answer |
|---|---|
| What morphological features is classic in the megaloblastic anemias? | macroovalocytes |
| A macrocytosis that is not megaloblastic in origin can be seen in all of the following: | Chemotherapy, Postsplenectomy, and reticulocytosis |
| A macrocytosis that is not megaloblastic in origin can be seen in all of the following except: | Hypoglycemic patients |
| Ineffective erythropoiesis is defined as: | Premature destruction of red cell precursors |
| Intrinsic factor is secreted by the: | Parietal cells of the stomach |
| One of the most common pathophysiologies that contribute to folic acid deficiency is: | Tropical sprue |
| The Schilling test continues to be an historic reference method for the determination of: | Pernicious anemia |
| Macrocytic red blood cells are routinely seen in all the following: | Pernicious anemia, liver disease, and response to anemic stress |
| Macrocytic red blood cells are routinely seen in all the following except: | Thalassemia |
| Thalassemia are characterized by: | Decreased rate of globin synthesis |
| When platelets concentrate at the edges and feathered end of a blood smear, it is usually due to: | poorly made wedge smear |
| Irregular clumping of platelets is usually due to: | inadequate mixing of blood and anticoagulant |
| The anemia of chronic infection is characterized by: | decreased serum iron levels |
| Factors commonly involved in producing anemia in patients with chronic renal disease include: | ineffective erythropoiesis |
| A pt has the following blood values: RBC 6.5 x 10^6/uL Hgb 14.0 g/uL Hct 42.0% MCV 65 fL MCH 21.5 pg MCHC 33% These results are compatible with: | thalassemia minor |
| What sets of laboratory findings is consistant with hemolytic anemia? | decreased erythrocyte survival; increased catabolism of heme |
| Evidence indicates that the genetic defect in alpha thalassemia usually results in: | a quantitative deficiency in RNA resulting in decreased globin chain production |
| Hemoglobin H disease results from: | absence of 3 of 4 alpha genes |
| What represents characteristic features of iron metabolism in patients with anemia of a chronic disorder? | serum iron is decreased, transferrin saturation is decreased, TIBC is normal or decreased |
| What is most closely associated with idiopathic hemochromatosis? | iron overload in tissue |
| What is seen most often in thalassemia? | target cells |
| What is most likely to be seen in lead poisoning? | basophilic stippling |
| A 17-year-old boy is admitted to the hospital with a fever of unknown origin. His WBC count is 20.0 x 10^9/L. All of the following can be seen on his peripheral smear: | toxic granulation, increased band neutrophils, and dohle bodies Can NOT be seen: reactive monocytes |
| A typical blood picture in infectious mononucleosis is an absolute: | Lymphocytosis without anemia and many reactive lymphocytes |
| A patient who presents with low white cell count, thrombocytopenia, elevated liver enzymes, and mulberry-like inclusions in the granulocytes is most likely suffering from: | Human ehrlichiosis |
| What statement is common to most lipid storage disease? | They are caused by a missing metabolic enzyme |
| An autosomal disorder that manifests itself with large lysosomal inclusions, recurring infections, and albinism is: | Chediak-Higashi |
| What is an unusual complication that may occur in infectious mononucleosis? | Hemolytic anemia |
| Toxic vacuolization occurs most frequently in: | Neutrophils |
| Toxic granulation in neutrophils is a direct result of: | Enhanced lysosome enzyme production |
| Pelger-Huet anomaly is characterized mainly by: | Hyposegmentation of the nucleus in the neutrophils |
| Dohle bodies consist of: | Ribosomal RNA |
| In which white cell disorder will you see prominent deposition of granules in every cell line? | Alder's anomaly |
| In which white cell disorder will you see gray-green cytoplasmic granules in the neutrophils? | Chediak-Higashi sydrome |
| All of the following are lipid storage syndromes/disease: | Gaucher's disease, Tay-Sachs disease, Niemann-Pick disease NOT: Chediak-Higashi syndrome |
| What shows the three stages of iron defiency anemia in order form first to third? | storage, transport, functional |
| What is not a cause of iron deficiency anemia? | chronic infection |
| In anemia of chronic inflammation, which is increased? | Storage iron |
| In sideroblastic anemia, where is there a decreased amount of iron? | Hemoglobin |
| Lead poisoning is associated with: | Sideroblastic anemia |
| What is the cause of primary iron overload? | defective genes |
| Iron overload damages all of the following cells: | liver tissue, white blood cells, pancreas tissue Not damaged: red blood cells |
| What is the common treatment for patients with hereditary hemochromatosis? | phlebotomy |
| What is the common treatment for patients with transfusion-induced hemochromatosis? | chelation |
| What can cause a B12 deficiency? | pernicious anemia |
| Lab finding common for megaloblastic anemia include all of the following: | pancytopenia, increased MCV, and nuclear-cytoplasmic asynchrony Not included: schistocytes |
| Long term megaloblastic anemia leads to what change in all the blood cell counts? | Decreased |
| Megaloblastic anemias result in cells that are: | macrocytic, normochromic |
| In a megaloblastic anemia, what result would be expected for a neutrophil lobe count? | increased |
| In a megaloblastic anemia, what result would be expected for a bilirubin test? | increased |
| In a megaloblastic anemia, what result would be expected for a lactate dehydrogenase? | Increased |
| A bone marrow aspiration/examination is not necessary for patients with megaloblastic anemia. | True |
| Hypersegmented neutrophils | megaloblastic anemia--specifically: pernicious anemia |
Created by:
Megan Hohenberg
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