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Test 2 - Chapters 5,6,10
|What morphological features is classic in the megaloblastic anemias?
|A macrocytosis that is not megaloblastic in origin can be seen in all of the following:
|Chemotherapy, Postsplenectomy, and reticulocytosis
|A macrocytosis that is not megaloblastic in origin can be seen in all of the following except:
|Ineffective erythropoiesis is defined as:
|Premature destruction of red cell precursors
|Intrinsic factor is secreted by the:
|Parietal cells of the stomach
|One of the most common pathophysiologies that contribute to folic acid deficiency is:
|The Schilling test continues to be an historic reference method for the determination of:
|Macrocytic red blood cells are routinely seen in all the following:
|Pernicious anemia, liver disease, and response to anemic stress
|Macrocytic red blood cells are routinely seen in all the following except:
|Thalassemia are characterized by:
|Decreased rate of globin synthesis
|When platelets concentrate at the edges and feathered end of a blood smear, it is usually due to:
|poorly made wedge smear
|Irregular clumping of platelets is usually due to:
|inadequate mixing of blood and anticoagulant
|The anemia of chronic infection is characterized by:
|decreased serum iron levels
|Factors commonly involved in producing anemia in patients with chronic renal disease include:
|A pt has the following blood values: RBC 6.5 x 10^6/uL Hgb 14.0 g/uL Hct 42.0% MCV 65 fL MCH 21.5 pg MCHC 33% These results are compatible with:
|What sets of laboratory findings is consistant with hemolytic anemia?
|decreased erythrocyte survival; increased catabolism of heme
|Evidence indicates that the genetic defect in alpha thalassemia usually results in:
|a quantitative deficiency in RNA resulting in decreased globin chain production
|Hemoglobin H disease results from:
|absence of 3 of 4 alpha genes
|What represents characteristic features of iron metabolism in patients with anemia of a chronic disorder?
|serum iron is decreased, transferrin saturation is decreased, TIBC is normal or decreased
|What is most closely associated with idiopathic hemochromatosis?
|iron overload in tissue
|What is seen most often in thalassemia?
|What is most likely to be seen in lead poisoning?
|A 17-year-old boy is admitted to the hospital with a fever of unknown origin. His WBC count is 20.0 x 10^9/L. All of the following can be seen on his peripheral smear:
|toxic granulation, increased band neutrophils, and dohle bodies Can NOT be seen: reactive monocytes
|A typical blood picture in infectious mononucleosis is an absolute:
|Lymphocytosis without anemia and many reactive lymphocytes
|A patient who presents with low white cell count, thrombocytopenia, elevated liver enzymes, and mulberry-like inclusions in the granulocytes is most likely suffering from:
|What statement is common to most lipid storage disease?
|They are caused by a missing metabolic enzyme
|An autosomal disorder that manifests itself with large lysosomal inclusions, recurring infections, and albinism is:
|What is an unusual complication that may occur in infectious mononucleosis?
|Toxic vacuolization occurs most frequently in:
|Toxic granulation in neutrophils is a direct result of:
|Enhanced lysosome enzyme production
|Pelger-Huet anomaly is characterized mainly by:
|Hyposegmentation of the nucleus in the neutrophils
|Dohle bodies consist of:
|In which white cell disorder will you see prominent deposition of granules in every cell line?
|In which white cell disorder will you see gray-green cytoplasmic granules in the neutrophils?
|All of the following are lipid storage syndromes/disease:
|Gaucher's disease, Tay-Sachs disease, Niemann-Pick disease NOT: Chediak-Higashi syndrome
|What shows the three stages of iron defiency anemia in order form first to third?
|storage, transport, functional
|What is not a cause of iron deficiency anemia?
|In anemia of chronic inflammation, which is increased?
|In sideroblastic anemia, where is there a decreased amount of iron?
|Lead poisoning is associated with:
|What is the cause of primary iron overload?
|Iron overload damages all of the following cells:
|liver tissue, white blood cells, pancreas tissue Not damaged: red blood cells
|What is the common treatment for patients with hereditary hemochromatosis?
|What is the common treatment for patients with transfusion-induced hemochromatosis?
|What can cause a B12 deficiency?
|Lab finding common for megaloblastic anemia include all of the following:
|pancytopenia, increased MCV, and nuclear-cytoplasmic asynchrony Not included: schistocytes
|Long term megaloblastic anemia leads to what change in all the blood cell counts?
|Megaloblastic anemias result in cells that are:
|In a megaloblastic anemia, what result would be expected for a neutrophil lobe count?
|In a megaloblastic anemia, what result would be expected for a bilirubin test?
|In a megaloblastic anemia, what result would be expected for a lactate dehydrogenase?
|A bone marrow aspiration/examination is not necessary for patients with megaloblastic anemia.
|megaloblastic anemia--specifically: pernicious anemia