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Hematology 1

Test 2 - Chapters 5,6,10

QuestionAnswer
What morphological features is classic in the megaloblastic anemias? macroovalocytes
A macrocytosis that is not megaloblastic in origin can be seen in all of the following: Chemotherapy, Postsplenectomy, and reticulocytosis
A macrocytosis that is not megaloblastic in origin can be seen in all of the following except: Hypoglycemic patients
Ineffective erythropoiesis is defined as: Premature destruction of red cell precursors
Intrinsic factor is secreted by the: Parietal cells of the stomach
One of the most common pathophysiologies that contribute to folic acid deficiency is: Tropical sprue
The Schilling test continues to be an historic reference method for the determination of: Pernicious anemia
Macrocytic red blood cells are routinely seen in all the following: Pernicious anemia, liver disease, and response to anemic stress
Macrocytic red blood cells are routinely seen in all the following except: Thalassemia
Thalassemia are characterized by: Decreased rate of globin synthesis
When platelets concentrate at the edges and feathered end of a blood smear, it is usually due to: poorly made wedge smear
Irregular clumping of platelets is usually due to: inadequate mixing of blood and anticoagulant
The anemia of chronic infection is characterized by: decreased serum iron levels
Factors commonly involved in producing anemia in patients with chronic renal disease include: ineffective erythropoiesis
A pt has the following blood values: RBC 6.5 x 10^6/uL Hgb 14.0 g/uL Hct 42.0% MCV 65 fL MCH 21.5 pg MCHC 33% These results are compatible with: thalassemia minor
What sets of laboratory findings is consistant with hemolytic anemia? decreased erythrocyte survival; increased catabolism of heme
Evidence indicates that the genetic defect in alpha thalassemia usually results in: a quantitative deficiency in RNA resulting in decreased globin chain production
Hemoglobin H disease results from: absence of 3 of 4 alpha genes
What represents characteristic features of iron metabolism in patients with anemia of a chronic disorder? serum iron is decreased, transferrin saturation is decreased, TIBC is normal or decreased
What is most closely associated with idiopathic hemochromatosis? iron overload in tissue
What is seen most often in thalassemia? target cells
What is most likely to be seen in lead poisoning? basophilic stippling
A 17-year-old boy is admitted to the hospital with a fever of unknown origin. His WBC count is 20.0 x 10^9/L. All of the following can be seen on his peripheral smear: toxic granulation, increased band neutrophils, and dohle bodies Can NOT be seen: reactive monocytes
A typical blood picture in infectious mononucleosis is an absolute: Lymphocytosis without anemia and many reactive lymphocytes
A patient who presents with low white cell count, thrombocytopenia, elevated liver enzymes, and mulberry-like inclusions in the granulocytes is most likely suffering from: Human ehrlichiosis
What statement is common to most lipid storage disease? They are caused by a missing metabolic enzyme
An autosomal disorder that manifests itself with large lysosomal inclusions, recurring infections, and albinism is: Chediak-Higashi
What is an unusual complication that may occur in infectious mononucleosis? Hemolytic anemia
Toxic vacuolization occurs most frequently in: Neutrophils
Toxic granulation in neutrophils is a direct result of: Enhanced lysosome enzyme production
Pelger-Huet anomaly is characterized mainly by: Hyposegmentation of the nucleus in the neutrophils
Dohle bodies consist of: Ribosomal RNA
In which white cell disorder will you see prominent deposition of granules in every cell line? Alder's anomaly
In which white cell disorder will you see gray-green cytoplasmic granules in the neutrophils? Chediak-Higashi sydrome
All of the following are lipid storage syndromes/disease: Gaucher's disease, Tay-Sachs disease, Niemann-Pick disease NOT: Chediak-Higashi syndrome
What shows the three stages of iron defiency anemia in order form first to third? storage, transport, functional
What is not a cause of iron deficiency anemia? chronic infection
In anemia of chronic inflammation, which is increased? Storage iron
In sideroblastic anemia, where is there a decreased amount of iron? Hemoglobin
Lead poisoning is associated with: Sideroblastic anemia
What is the cause of primary iron overload? defective genes
Iron overload damages all of the following cells: liver tissue, white blood cells, pancreas tissue Not damaged: red blood cells
What is the common treatment for patients with hereditary hemochromatosis? phlebotomy
What is the common treatment for patients with transfusion-induced hemochromatosis? chelation
What can cause a B12 deficiency? pernicious anemia
Lab finding common for megaloblastic anemia include all of the following: pancytopenia, increased MCV, and nuclear-cytoplasmic asynchrony Not included: schistocytes
Long term megaloblastic anemia leads to what change in all the blood cell counts? Decreased
Megaloblastic anemias result in cells that are: macrocytic, normochromic
In a megaloblastic anemia, what result would be expected for a neutrophil lobe count? increased
In a megaloblastic anemia, what result would be expected for a bilirubin test? increased
In a megaloblastic anemia, what result would be expected for a lactate dehydrogenase? Increased
A bone marrow aspiration/examination is not necessary for patients with megaloblastic anemia. True
Hypersegmented neutrophils megaloblastic anemia--specifically: pernicious anemia
Created by: Megan Hohenberg