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Hematology 1
Hematology in Practice - Chapter 8
| Question | Answer |
|---|---|
| The hemoglobin variant that is seen frequently in the Southeast Asian population, and migrates with Hgb C at pH 8.6, is: | E |
| A patient with sickle cell anemia may develop cardiopulmonary disease due to: | High blood viscosity |
| The Benin haplotype of sickle cell disease is prevalent in which country or countries? | West Africa |
| What "poikilocytes" are classically associated who hemoglobinopathies and liver disease? | Target cells |
| Painful swelling of hands and feet caused by sickle cells in the microcirculation of sickle cells in infants is termed: | Dactylitis |
| Patients with sickle cell anemia generally have a hemoglobin value between: | 6 and 8 g/dL |
| Alkaline electrophoresis will not separate hemoglobin C from: | Hemoglobin A2 |
| _____ is the second most common hemoglobin variant worldwide. | Hemoglobin E |
| The qualitative hemoglobinopathies cause disease by producing hemoglobin chains that are: | structurally altered |
| What clinical feature of sickle cell disease accounts for the highest number of hospital admissions? | Vaso-occlusion |
| What percentage of African Americans have heterozygous sickle cell trait? | 8% |
| What is the probable etiologic association between malaria and sickle cell trait? | Sickle genes offers some protection against malaria. |
| A patient has target cells and a positive tube solubility test. This patient probably: | has either sickle cell anemia or trait |
| Moderate to marked target cells are found on a blood smear. Which of the following can most likely by eliminated? A. hemoglobin C disease B. Hereditary spherocytosis C. Hemoglobin E disease D. liver disease | B. Hereditary spherocytosis |
| What is a typical finding in patients with hemoglobin M? | Elevated methemoglobin |
| What is the correct relationship between red cells' affinity for oxygen and red cell production? | When affinity is high, less oxygen is released and the body compensates by increasing erythropoietin and making more red cells. |
| What is the amino acid substitution in patients with sickle cell anemia? | Valine for glutamic acid |
| What factor contributes to the pathophysiology of sickling? | Dehydration |
| What statement pertains to most clinically significant hemoglobin variants? | Most are single amino acid substitutions |
| What hemoglobin ranks second in variant hemoglobins worldwide? | Hgb E |
| Which shows crystals appearing like bars of gold in the peripheral smear? | Hgb CC disease |
| What condition is the leading cause of hospitalization for sickle cell patients? | Acute chest syndrome |
| What hemoglobin separation method is used for most newborn hemoglobin screening? | Isoelectric focusing |
| Autosplenectomy is characteristic of: | Sickle cell anemia |
| The Benin haplotype of sickle cell disease is prevalent in which country or countries? | West Africa |
| When the bone marrow temporarily ceases to produce cells in a sickle cell patient, an ______ crisis has occurred. | Aplastic |
Created by:
Megan Hohenberg
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