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Hematology 1

Hematology in Practice - Chapter 5

Transferrin receptors for iron uptake are located on the: Pronormoblast
In addition to iron ingestion, over 90% of iron in adults that is used for erythropoiesis is obtained through: Recycling of iron
All of the following are symptoms of iron deficiency anemia except: A. Pallor B. Pica C. Vertigo D. Numbness D. Numbness
Ringed sideroblasts in the bone marrow are characteristics of which of the following disorders? Sideroblastic Anemia
Which type of inclusion is likely to be seen in the above patient? Pappenheimer bodies
The alpha thalassemic condition that is incompatible with life is: Bart's hydrops fetalis
Failure to thrive, facial structure abnormalities, severe anemia, and splenomegaly are signs of what disorder? Thalassemia major
What laboratory tests would be abnormal through each stage of iron deficiency? Serum ferritin
What is true regarding iron absorption? Ascorbic acid (vitamin C) enhances absorption
Heme is composed of iron and: protoporphyrin IX
Good dietary sources of iron include all except: A. Meat B. Fruit C. Fortified flour D. Legumes B. Fruit
What are the major storage sites for iron in a normal individual? liver and spleen
A markedly decreased iron percent saturation is consistent with: iron deficiency
A bone marrow Prussian blue stain shows blue granules inside of macrophages. What disorder can be ruled out? Iron deficiency
What is true about iron absorption? It must be in ferrous form for absorption.
Lack of accessible iron is the mechanism for iron deficiency and what? Anemia of chronic inflammation
Where is most of the iron in the body found? Attached to hemoglobin in the red blood cells
What results are typical in stage 3 iron deficiency anemia? Low mean cell volume (MCV), mean cell hemoglobin (MCH), and mean cell hemoglobin concentration (MCHC)
What is the mechanism for the anemia in chronic inflammation (ACI)? Hepcidin, lactoferrin, and ferritin impair iron mobilization
How does lead exposure and the porphyrias cause anemia? interfere with heme production
Why is too much iron dangerous? Free radicals and superoxide formed from ferrous iron plus oxygen damage cell membranes
What is true of stage 3 iron deficiency? Free erythrocyte protoporphyrin (FEP) is increased
What would point to iron deficiency anemia (IDA) as opposed to the anemia of chronic inflammation (ACI)? High transferrin
What is the basic hemoglobin defect in the thalassemias? A structurally normal globin chain is absent or produced at lower levels.
What is the primary mechanism for anemia in the thalassemias? An imbalance in the rate of globin chain synthesis
What is expected findings in beta-thalassemia minor? Basophilic stippling
Homozygous alpha-thalassemia (-/-) has what clinical outcome? incompatible with life
In regards to the thalassemias, the deficit has nothing to do with iron. True
The morphologic classification of anemias is based on the: Red blood cell indices
What symptom is specific for IDA? Koilonychia
What laboratory test would be abnormal through each stage of iron deficiency? Serum ferritin
A patient presents with a microcytic, hypochromic anemia with ragged-looking red blood cells in the peripheral smear and a high reticulocyte count. A brilliant cresyl blue preparation reveals inclusions that look like pitted golf balls. What disease? Hgb H disease
The most cost-effective therapy for a patient with hereditary hemochromatosis is: therapeutic phlebotomy
List two sets of laboratory data that can distinguish IDA from beta thalassemia trait: Serum iron and RBC
What is the majority hemoglobin in thalassemia major? Hgb F
Of the four clinical states of alpha thalassemia, which is incompatible with life? Bart's hydrops fetalis
What hemoglobin has the chemical confirmation B4? Hgb H
Although there are many complications in individuals with thalassemia major, what is the leading cause of death? Cardiac complications
Created by: Megan Hohenberg