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Hematology 1

Hematology in Practice - Chapter 3

The erythrocyte stage that marks the beginning of hemoglobinization is called: Polychromatophilic normoblast
The red cell protein that is responsible for deformability and flexibility of the red cell is: Spectrin
What is the RBC pathways is responsible for providing 90% of the cellular AATP for red cell metabolism? Embden-Meyerhof pathway
The basic pathophysiology of the thalassemic conditions is a: Decreased or absent globin chain synthesis
Polychromatophilic macrocytes in the peripheral smear are most likely: Reticulocytes
The degree of effective erythropoietic activity in any hematological disorder is most readily assessed by a: Reticulocyte count
Most hypochromic cells will have an MCHC that is: Less than 30%
The last nucleated stage of erythrocytic maturation is the: Orthochromic normoblast
From each pronormoblast precursor cell, ____ mature red blood cells are produced. 16
The higher the N:C ratio, the more mature the cell. False
One of the key morphological features of the nucleated red cell stages is: A round nucleus
Increased plasma cholesterol may lead to the development of which of these abnormal red cell morphologies? Target cells
The hemoglobin molecule consists of: four heme molecules, four globin chains
Asynchrony in the bone marrow is defined as the: Nuclear development and hemoglobin development that is unbalanced
The red cell inclusion derived from denatured hemoglobin are: Heinz bodies
When hemolysis is produced by the intravascular fragmentation of red cells, which red cell morphology will be produced? Schistocytes
Red cell inclusions that are remnants of DNA are termed: Howell Jolly bodies
Pappenheimer bodies are composed of: Iron
Reversible sickled cells are described as having a: Half-moon shape with rounded ends
The anucleate mature red blood cell has no ability to produce protein. True
What is a significant morphologic difference between irreversibly sickled cells and reversible sickled cells? Pointed projections to the sickle cell
What are two integral proteins in the red blood cell structure that house red blood cell antigens? Glycophorin A and glycophorin B
All are characteristic of the red blood cell in stages of development: nuclei are "baseball round", immature cells are larger, N:C ratio decreases as the cell matures
A characteristic that is not a stage of development of the red blood cell: distinct granulation in the cytoplasm
What red blood cell inclusions originate as a result of denatured hemoglobin? Heinz bodies
In which conditions can you see elliptocytes? Iron deficiency anemia
What red blood cell morphology may form as a result of excess cholesterol taken on the red blood cell membrane? Target cells
Hypochromia is used to define: Decrease in hemoglobin content of the red blood cell
The erythrocyte stage that marks the beginning of hemoglobinization is called: Polychromatophilic normoblast
A key morphologic feature of the nucleated red blood cell stages is : "Baseball" round nucleus
The red blood cell protein that is responsible for deformability and flexibility of the red blood cell is: Spectrin
Created by: Megan Hohenberg