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physiology-cell
Stack #187900
| Question | Answer |
|---|---|
| Townes and Holtfreter experiment, and what it implies | like cells from different embryos aggregate, adhere together. implies cell recognition, cell adhesion |
| __ folding of peptide in transmembrane domain | alpha helix |
| glycocalyx responsible for | cell recognition (ABO blood types), cell adhesion |
| types of CAM (cell adhesion molec) | 1.cadherin - homophilic binding 2.integrin - heterophilic binding |
| how to dissociate cell | remove Ca2_, or add trypsin |
| spatiotemporal distribution | lose CAM to migrate, re-express CAM to group into ganglia |
| cell junctions | occluding (tight junction), anchoring , gap |
| types of anchoring junction | 1. adherens - cell-cell or cell-matrix E-cadherin @ catenin attached to F-actin 2. desmosome - cell to cell catenin attached to non contractile IF. 3. hemidesmosome - cell to basal lamina |
| 1 gap junction is | 2 connexon, (6 * 2 connexin) |
| facilated diffusion passive or active | passive |
| difference between facilitated diffusion and simple diffusion through channels | both passive, but facilitated diffusion has a binding site |
| what diffusions are carrier mediated | facilitated diff, primary, secondary active |
| effect of insulin on glucose transpoter | increase number of Glut4 |
| Glut 4 is an example of what kind of transport | facilitated diffusion |
| facilitated diffusion move molec against/down conc't grad | down |
| co-transport also called | symport |
| counter-transport also called | antiport |
| example of co-trasport in kidney | gluc and Na+ moving into cell from lumen of nephron |
| example of counter-trasport in kidney | Na+ move into cell and H+ out to lumen of nephron |
| fluid endocytosis called | pinocytosis |
| during endocytosis phagosome fuse with | lysosome |
| during pinocytosis pinocytic vesicle fuses with | endosome |
| pseudopod formed during phago or pinocytosis | during phagocytosis |
| rheumatoid arthritis | autoimmune disorder causes release of lysosomal content into joints |
| lysosomal storage disorder | tay sach, missing lipase in lysosome => accum of FA in brain |
| receptor mediated endocytosis (special pinocytosis) | 1.clathrin bdd to vesicle 2.clathrin removed 3.vesicle bdd to endosome |
| what kind of molec taken in by receptor mediated endocytosis | LDL |
| autocrine cell affect | itself |
| paracrine cell affects | target cell |
| where does RNA polymerase bind to | promotor region |
| exons are | expressed genes |
| introns are | garbage ie not expressed |
| familial hypercholesterolemia | LDL receptor defective, high LDL in blood causing atherosclerosis |
| intracellular protein made in | free ribosome |
| protein destined for secretion made in | RER |
| protein destined for integration into membrane made in | RER |
| co-translational modification | translation starts in free ribosome. signal sequence binds SRP(signal recognition particle) which takes the complex to ribosome on RER, where translation is continued. |
| how does steroid hormone (lipid soluble ligand) bring about intracellular response? | steriod diffuse accross PM, and bdd to intracellular receptor. the receptor-ligand complex moves into the nucleus, where it will act as a transcription factor. |
| subunit of MF | actin |
| subunit of MT | alpha, beta tubulin |
| what is the strongest cytoskeletal filament | microtubule |
| what forms a hollow filament | MT |
| IF forms | nuclear lamina |
| MT radiates from | centromere |
| dynein moves tward __ this is called | -ve, reterograde |
| kinesin moves toward __ this is called | +ve, anterograde |
| what acts as a track for dynein, kinesin | MT |
| endothelial cells of nephron held together by | tight junction |
| integrin | heterophilic CAM |
| cadherin | homophilic CAM |