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Biochem-ETOH Metab

Biochem-Alcohol Metabolism-WVSOM Class of 2012

in the MEOS system, what enzyme is used? cytochrome p450 enzyme cyp2e1
what is the cofactor in the meos system? is this molecule oxidized or reduced? nadph; oxidized
what can the liver make out of acetyl coa? go into tca, fa synthesis, cholesterol synthesis, ketone synthesis
how can nadh make energy? ox phos, various dehydrogenases
what tissues aside from liver can use acetate? kidney, heart, skeletal muscle
which adh isoenzyme has highest km in liver adh2
excessive nadh increases what reactions? g-3-p production, lactate production, and malate production
excessive nadh decreases what reactions? tca activity, b-oxidation, and glycolysis
what is effect of excess acetaldehyde on protein? decrease synthesis, decrease lipoprotein synthesis, decrease lipoprotein export
why does ketoacidosis occur in high etoh intake? decrease tca cycle activity, decreased acetyl coa going into the tca cycle, increased use of acetate instead of ketones
why does gout occur in increased etoh levels? uric acid competes with lactate for excretion
why do carbon sources decrease for gluconeogenesis inhigh etoh levels? decreased alanine available, g-3-p not converted to dihydroxyacetone phosphate
glutathione aside, how else do reactive oxygen species occur in increased etoh? increased cyp2e1 and increased p450 enzymes
where does the meos system occur? on the ER
which aldh is mitochondrial? which is major oxidizer of aldh? aldh2; aldh2
decreased acetaldehyde clearance more commono in heterozygotes or homozygotes? homozygotes
high nadh levels may exceed liver's ability to oxidize via what pathway? oxidative phos
why does tca cycle activity decrease in high nadh? allosteric inhibition of isocitrate dehydrogenase
why does b-oxidation decrease in high nadh? not enough nad substrate
why does glycolysis activity decrease in high nadh? decreased g3pd activity due to lack of substrate
why does g3p activity increase in high nadh? can't go forward from dihydroxyacetone through glycolysis due to decreased g3pd activity
why does lactate production increase in high nadh? reaction uses increased nadh to move reaction from pyruvate to lactate
why does malate production increase in high nadh? malate comes from oxaloacetate due to nadh favoring that direction of the reaction
what things contribute to fatty liver? increased g3p activity and decreased b-oxidation result in increased trigylceride synthesis
in a pathological situation, what does acetaldehyde bind to? amino acids
what lipoprotein contributes to fatty liver? vldl
why does gluconeogenesis decrease in high nadh? decreased dihydroxyacetone, pyruvate, and alanine substrates
Created by: mhassan