Busy. Please wait.
or

show password
Forgot Password?

Don't have an account?  Sign up 
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Didn't know it?
click below
 
Knew it?
click below
Don't know (0)
Remaining cards (0)
Know (0)
0:00
share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Biochem-ETOH Metab

Biochem-Alcohol Metabolism-WVSOM Class of 2012

QuestionAnswer
in the MEOS system, what enzyme is used? cytochrome p450 enzyme cyp2e1
what is the cofactor in the meos system? is this molecule oxidized or reduced? nadph; oxidized
what can the liver make out of acetyl coa? go into tca, fa synthesis, cholesterol synthesis, ketone synthesis
how can nadh make energy? ox phos, various dehydrogenases
what tissues aside from liver can use acetate? kidney, heart, skeletal muscle
which adh isoenzyme has highest km in liver adh2
excessive nadh increases what reactions? g-3-p production, lactate production, and malate production
excessive nadh decreases what reactions? tca activity, b-oxidation, and glycolysis
what is effect of excess acetaldehyde on protein? decrease synthesis, decrease lipoprotein synthesis, decrease lipoprotein export
why does ketoacidosis occur in high etoh intake? decrease tca cycle activity, decreased acetyl coa going into the tca cycle, increased use of acetate instead of ketones
why does gout occur in increased etoh levels? uric acid competes with lactate for excretion
why do carbon sources decrease for gluconeogenesis inhigh etoh levels? decreased alanine available, g-3-p not converted to dihydroxyacetone phosphate
glutathione aside, how else do reactive oxygen species occur in increased etoh? increased cyp2e1 and increased p450 enzymes
where does the meos system occur? on the ER
which aldh is mitochondrial? which is major oxidizer of aldh? aldh2; aldh2
decreased acetaldehyde clearance more commono in heterozygotes or homozygotes? homozygotes
high nadh levels may exceed liver's ability to oxidize via what pathway? oxidative phos
why does tca cycle activity decrease in high nadh? allosteric inhibition of isocitrate dehydrogenase
why does b-oxidation decrease in high nadh? not enough nad substrate
why does glycolysis activity decrease in high nadh? decreased g3pd activity due to lack of substrate
why does g3p activity increase in high nadh? can't go forward from dihydroxyacetone through glycolysis due to decreased g3pd activity
why does lactate production increase in high nadh? reaction uses increased nadh to move reaction from pyruvate to lactate
why does malate production increase in high nadh? malate comes from oxaloacetate due to nadh favoring that direction of the reaction
what things contribute to fatty liver? increased g3p activity and decreased b-oxidation result in increased trigylceride synthesis
in a pathological situation, what does acetaldehyde bind to? amino acids
what lipoprotein contributes to fatty liver? vldl
why does gluconeogenesis decrease in high nadh? decreased dihydroxyacetone, pyruvate, and alanine substrates
Created by: mhassan
 

 



Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then tap the card to flip it. If you knew the answer, tap the green Know box. Otherwise, tap the red Don't know box.

When you've placed seven or more cards in the Don't know box, tap "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just tap on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards