Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Biochem-ETOH Metab
Biochem-Alcohol Metabolism-WVSOM Class of 2012
| Question | Answer |
|---|---|
| in the MEOS system, what enzyme is used? | cytochrome p450 enzyme cyp2e1 |
| what is the cofactor in the meos system? is this molecule oxidized or reduced? | nadph; oxidized |
| what can the liver make out of acetyl coa? | go into tca, fa synthesis, cholesterol synthesis, ketone synthesis |
| how can nadh make energy? | ox phos, various dehydrogenases |
| what tissues aside from liver can use acetate? | kidney, heart, skeletal muscle |
| which adh isoenzyme has highest km in liver | adh2 |
| excessive nadh increases what reactions? | g-3-p production, lactate production, and malate production |
| excessive nadh decreases what reactions? | tca activity, b-oxidation, and glycolysis |
| what is effect of excess acetaldehyde on protein? | decrease synthesis, decrease lipoprotein synthesis, decrease lipoprotein export |
| why does ketoacidosis occur in high etoh intake? | decrease tca cycle activity, decreased acetyl coa going into the tca cycle, increased use of acetate instead of ketones |
| why does gout occur in increased etoh levels? | uric acid competes with lactate for excretion |
| why do carbon sources decrease for gluconeogenesis inhigh etoh levels? | decreased alanine available, g-3-p not converted to dihydroxyacetone phosphate |
| glutathione aside, how else do reactive oxygen species occur in increased etoh? | increased cyp2e1 and increased p450 enzymes |
| where does the meos system occur? | on the ER |
| which aldh is mitochondrial? which is major oxidizer of aldh? | aldh2; aldh2 |
| decreased acetaldehyde clearance more commono in heterozygotes or homozygotes? | homozygotes |
| high nadh levels may exceed liver's ability to oxidize via what pathway? | oxidative phos |
| why does tca cycle activity decrease in high nadh? | allosteric inhibition of isocitrate dehydrogenase |
| why does b-oxidation decrease in high nadh? | not enough nad substrate |
| why does glycolysis activity decrease in high nadh? | decreased g3pd activity due to lack of substrate |
| why does g3p activity increase in high nadh? | can't go forward from dihydroxyacetone through glycolysis due to decreased g3pd activity |
| why does lactate production increase in high nadh? | reaction uses increased nadh to move reaction from pyruvate to lactate |
| why does malate production increase in high nadh? | malate comes from oxaloacetate due to nadh favoring that direction of the reaction |
| what things contribute to fatty liver? | increased g3p activity and decreased b-oxidation result in increased trigylceride synthesis |
| in a pathological situation, what does acetaldehyde bind to? | amino acids |
| what lipoprotein contributes to fatty liver? | vldl |
| why does gluconeogenesis decrease in high nadh? | decreased dihydroxyacetone, pyruvate, and alanine substrates |
Created by:
mhassan
Popular Biochemistry sets