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Phys endocrine disea

WVSOM -- Physiology Endocrine Diseases

Growth Hormone Excess (pre-puberty) gigantism
Growth Hormone Excess (post-puberty) acromegally, increased organ size, glucose intolerance
Prolactin deficiency Failure to lacate
Factors that increase prolactin secretion estrogen, breast-feeding, sleep, stress, TRH, dopamine antagonists
Factors that decrease prolactin secretion deopamine, bromocriptine, somatostatin, prolactin
Hyperthyroidism symptoms increased metabolic rate, weight loss, negative Nitrogen balance, incrased heat production, increased cardiac output, dyspnea, tremor, weakness, goiter
Hyperthyroid causes graves disease, thyroid neoplasm
Graves Disease Antibodies to TSH receptor
TSH Levels in Hyperthyroidism decreased
Addison’s Disease autoimmune destruction of adrenal cortex; Primary adrenocortical insufficiency
Clinical features of Addison’s Disease hypoglycemia, anorexia, weight loss, nausea, vomiting, weakness, hypotension, Hyperkalemia, metabolic acidosis, decresased pubic and axillary hair in women
Cushing’s Syndrome adrenocortical excess; hyperplasia of adrenal glands….not to be confused with Cushing’s Disease
Clinical features of Cushing’s Syndrome hyperglycemia, muscle wasting, central obesity, round face, buffalo hump, osteoporosis, striae, verilzation and menstrual disorders in women, HTN
ACTH levels in Cushing’s decreased (negative feedback of cortisol)
Cushings Disease overproduction of ACTH; usually drug induced; same symptoms as Cushing Syndrome
Conn’s Syndrome aldosterone secreting tumor
Congenital Adrenal hyperplasia deficiency in CYP21A2, CYP11B1, CYP 17, StAR
CYP 17 deficiancy results in decreased cortisol production by slowing conversion of pregnelone and progesterone to the cortisol pathway
CYP11B1 deficiency decreased aldosterone and cortisol production
CYP21A2 deficiency decreased aldosterone and cortisol production
Hypothalmic Diabetes Insipidis Deficiency in ADH
Nephrogenic Diabetes Insipidis Renal resistance to ADH
Dipsogenic Diabetes Insipidis Excessive Water drinking
Created by: tjamrose