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Blood Bank
History , Genetics and ABO System
Question | Answer |
---|---|
Karl Landsteiner | Discovered ABO system |
Immunity | host organism protects itself from attacks by both external and internal agents |
IgG antibodies | most clinically significant. Reacts at 37. activate complement and HDN |
IgM | Naturally occurring. Room temp or colder. |
IgA | Can result in anaphylaxis |
Pathways of complement pathway | Classical, alternative,Lectin |
DAT Direct antiglobulin Testing | in vivo-in body. Involves detecting IgG antibodies. used for HDN,Transfusion rxn. autoimmune hemolytic anemia. |
IAT Indirect antigloublin testing. | in vitro. detect blood group antibodies,prenatal. preventative testing. |
Amorph | Silent gene |
Dosage | antibody reacts more strongly with a red cell antigen due to homozygous expression |
Autosomal Recessive | homozygotes who have the gene from both parent. |
incompatible ABO type results in | almost immediate lysis of donor RBC |
Antibody is in | Serum |
Antigen in on | the RBC |
H antigen produces | transferase |
what is hh | bombay phenotype denoted Oh |
Group A sugar is on the RBC | N-acetyl-D-glactosamine |
Group B sugar is on the RBC | D-galactose |
Group O | L-fucose |
Which group has the least amount of H anitgen | A1B |
Which group has the greatest amount of H antigen | O |
Lectins used in Blood bank are | Dolichos Bifouros A1 Ulex europeaus H |
What are the group 1 disrepancies for reverse typing due to weakly reacting or missing antibodies | newborns, elderly, leukemia patients,immosupressive drugs,burn patients, ABO Sub groups. (resolve by heating) |
What is chimerism | 2 cell populations in one person. Bone marrow patients, fetal maternial bleed |