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Systemic lupus erythematosus chronic inflammatory condition affecting joint surfaces and vessel walls seen predominantly in women and young children genetic predisposition , seen in relatives with HLADR2 and HLADR3 antigens most common immunologic feature is production of ANA- immune complexes responsible for renal and cutaneous manifistations, tissue specific antibodies that cause hemolysis(RBC break down=brown urine) and thrombocytopenia(decreased platelets bleed rightaway effects joints and kidneys, serous surfaces, and vessel walls etiology is unkown ANA +
systemic manifestations include fatigue malaise weight loss fecer without signs of infection (blank) (blank)
cutaneous manifestations malar or butterfly rash exacerbated by exposure to sun discoid rash ( chicken skin) patchy alopecia (regional balding) (blank) (blank) (blank)
joint manifestations arthritis- symmetric primarily involving hands, wrist , and knees ligament laxity leads to joint deformaties raynaud's phenomenon - alternate red and whitediscoloration of skin secondary to exposure to cold weather (blank) (blank) (blank)
renal manifistation nephritic syndrome (Blood urea Nitrogen increases, lipid loss causes hypolipidemia, sensorial deterioration so drowsy and comatose, decrease albumin increases edema) renal failure ( can't produce urin) (blank) (blank) (blank) (blank)
neurologic manifistation behavioral and cognitive disturbances activive cerebritis( encephalitis) neuropathies cranial and peripheral (blank) (blank) (blank)
git manifestation nasea abdominal pain 2 to steril peritonitis (blank) (blank) (blank) (blank)
Cardio pulmonary manifestation pleuritis ( infl lung tissue) pneumonitis ( infl lung) pericarditis endocarditis ( infl of heart valves) (Libman sacs endocarditis) (blank)
hematologic manifestation hepatosplenomegaly normochronic, normocytic anemeia ( normal number and size of rbc can't sustain O2 leukopenia ( dec WBC) thrombocytopenia ( dec platelets) (blank) (blank)
treatment steroids and cytotoxic agents ( azthioprine , cyclophosphomide) for ppl with kidney problems, hemolytic anemia, and thrombocytopenia antimalarial agent for cutaneus manifistation and arthritis 9 hydroxycloroquin) analgesics like ASA, NSAID, or ibuprofin for mild systemic symptoms side effect of acytyl salilic acid is salycylate hepatitis side effect for nsaid is acute renal failure side effect for ibuprofin is aseptic meningitis
Created by: natkat