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Lecture 33

Renal Control-Secretion-Filtrate Dilution

Renin-Angiotensin System Maintain BP by inc Na+ and H2O reab. Dec renal BP leads to release of renin from kidney JG cells. Renin is a protease.
Production of Angiotensin 2 Renin converts angiotesinogen into angiotensin 1. Angiotensin converting enzyme (ACE) converts A1 to A2. ACE is in the walls of lung capillaries
Effects of Ang 2 Powerful vasoconstrictor leads to inc BP causes release of aldosterone from adrenal cortex.
ACE Inhibitors Block production of Ang. 2. used as treatment for hypertension. few side effects, but may produce fetal development problems.
Tubular Secretion Xtra removal from plasma, carries and pumps more material from tubular cells into filtrate. most secretion is at proximal tubule. organic acids and bases secreted:poisons,medicines,dyes,food additives.
Renal Blood Flow-PAH PAH is totally secreted from plasma. appearance in urine proportional to renal blood flow RBC ~ 20-25% of cardiac output.
H+ Secretion carbon,canhydrase in tubular cells makes H+ and HCO-. H+ secreted in both the proximal and distal tubules. uses Na+-H+ countertransport, H+ into filtrate. HCO3- leads to interstitial fluid,net loss of H+.
K+ Secretion K+ reabsorbed in exchange for NA+ in prximal tubule. the na+ pump actvity inc tubular cell K+ which inc its secretion by the proximal tubule cells. since k+ and h+ both exchange w/ na+, an inc in the secretion of one dec secretion of the other.
Plasma Clearance measure of kidneys ability to remove a sub. from the plasma. it is the vol of plasma, from which an amount of material has been removed.glucose has 0 clearance.if a sub is filtered but not secrted or reab like insulin,its plasma clearance is the GFR.
Loop of Henle Creates osmotic gradient in kidney medulla.300 mOsm at cortex,1200 mOsm in deep medulla. filtrate at the end of the loop is 100 mOsm. plasma is 300 mOsm.
Countercurrent Multiplication descending limb of loop is h2o permeable. ascending linb is h20 impermeable-h+,k+,cl- pumped out.filtrate entering distal tubule always dilute~100 mOsm
Plasma Clearance cont. if sub like PAH is filtered and entirely secreted,its plasma clearance is the renal blood flow~20-25% of CO>
Created by: danamarie9323