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neuroplasticity br
np br
| Question | Answer |
|---|---|
| The goal of therapy and plasticity is: | To induce new learning through activating new circuits. |
| What do the neighbors of dead neurons do? / | They start taking over the functions that the dead neurons used to do. |
| For the neighbors, what happens to their current job functions? | Those functions get passed along back and get kind of crowded out. |
| What is the second piece of plasticity? | Living neurons reach into the dead areas and try to live there. |
| how fast do neurons grow? | 1 mm/day |
| how long does it take to connect Broca's and Wernicke's areas | 6 months |
| what is required from the brain to recover from aphaisa | grow new connections |
| what is the purpose to growing new connections and new synapses when recovering from aphasia? | the idea is to have a way to encode information that has been lost |
| what is the goal of therapy | to shape the regrowth of neural connections |
| What are an early recover pattern things that Dr. Stead would like to see? | restoration and reorganization |
| what does dr. stead like to see in later recovery | compensation. |
| what is the ultimate goal | the ability to perform a task the same way as before. |
| what is the timeline of recovery? | 1. event 2. shock 3. reperfusion 4. physical repair 5. capitalization of intact areas 6 new learning |
| what is shock? | shock helps protect tissue and prevents death |
| what is reperfusion | when blood flow comes back on line |
| what is capitalization of intact areas | intact areas take over the damage areas skills |
| what are the largest indicators of prognosis? | etioloty (ischemic or hemorragic) tumor, progressive. how big it was what got hurt/take out. |
| which has better chances of recovery? right or left handed people | Left handed people are more likely to have bilateral use of language and better recovery |
| what is a block? | ischemic stroke |
| what is a bleed? | hemorrhagic stroke |
| what is the recovery pattern for ischemic stroke | greater and sooner recovery (the clot goes away) noticable recover in the first few weeks maximum recovery in 3 months 8-12% mortality |
| what is essential to maximum recover in ischemic strokes | clot busting drug TPA |
| what is the recovery pattern in hemorrhagic strokes? | little recovery in teh first 4-8 weeks (takes a while to repair torn walls. more rapid recover in 4-8 weeks stabilazion slowing with greater residual deficits. 38% mortality |
| what are some plasticity principles for treatment relating to dosage? p. 61 | use it or lose it, use it and improve it, specificity, repetition matters, intensity matters, time matters, salience matters, age matters, transference matters, interference |
| what are the primary changes (within a week) of a CVA? | immediate necrosis (cell death), signs of inflammation in the cell, retrograde cell degeneration proximal tot eh lesion and anterograde cell degeneration distal to the lesion. |
| what are the secondary changes? | trnasneuronal degeneration, denervation supersensitivity, development of diaschisis, vascular disruption, collateral sprouting |
| what are structural biochemical and physiologic mechanism of recovery? 2 | regenerative sprouting p.54 Collateral regenerative sprouting p.54 |
| what are funcitonal changes biochemical and physiological mechansism of recovery | relatively ineffective synapses denervation sensitivity synapse potentials |
| what are the behavioral mechanisms of recovery? restoration reactivation, restitution | 1. restitution-restoration-reactiviation. thi is the reactivation of temporarily impaired language function. |
| what is reorganization reconstitution and substitution withini a funciton system as a behavioral mechanism of recovery? | this is the rerouting of the communication lines in teh brain. using a different route to get to the same area. |
| what is relearing as a behavioral mechanism of recovery? | relearning how to do lost skills. |
| what is facilitation as a behavioral mechanism of recovery? | this is employed in the case of difficulty accessing intact information in a functional system. |
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