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SB82 Spleen
SB82 Spleen - loosely taken from Fiser's ABSITE review
| Question | Answer |
|---|---|
| Which organ is the largest producer of IgM? __________ | Spleen |
| What comprises Howell-Jolly bodies? __________ | Nuclear remnants |
| What comprises Heinz bodies? __________ | Hemoglobin |
| What is the definition of culling? | Removal of less deformable RBCs |
| What is the main site of clearance of bacteria that do not have pre-existing antibodies? ___________ | Spleen |
| Which opsonin that facilitates phagocytosis is produced in the spleen? ___________ | Tuftsin |
| Which substance produced in the spleen activated the alternate complement pathway? _______________ | Properdin |
| Accessory spleens are most commonly found in this location | Splenic hilum (20%) |
| Pathophysiology of ITP | IgG antiplatelet antibodies bind platelets, causing thrombocytopenia |
| Therapy for ITP | Steroids (primary therapy), plasmapheresis, gammaglobulin, splenectomy |
| What percentage of patients with ITP respond to splenectomy? | 80% |
| When should you give platelets prior to splenectomy for ITP? | One hour before surgery |
| What is the pathophysiology of TTP? | Loss of platelet inhibition causes thrombosis and infarction with profound thrombocytopenia |
| What percent of patients with TTP respond to medical therapy? | 80% |
| What is the treatment of TTP? | Plasmapheresis (primary); steroids, aspiring |
| Post-splenectomy sepsis is highest in patients who required splenectomy for what conditions? | Hemolytic disorders or malignancy |
| Most episodes of post-splenectomy sepsis occur within what time frame? | Within 2 years of splenectomy |
| Post-splenectomy changes in blood studies | Increased RBCs, increased WBCs, increased platelets |
| What is the most common benign splenic tumor? ___________ | Hemangioma |
| What is the indication for resection of splenic hemangioma? | Symptomatic |
| What is the most common malignant splenic tumor? ___________ | Non-Hodgkin’s lymphoma |
| When should you perform surgery for splenic cysts? | If they become symptomatic or are > 10 cm |
| This syndrome is characterized by rheumatoid arthritis, hepatomegaly, splenomegaly _________ | Felty’s syndrome |
| This lipid disorder leads to splenomegaly __________ | Gaucher’s disease |
| What is the most common congenital hemolytic anemia requiring splenectomy? _________ | Spherocytosis |
| What is the mutated protein causing spherocytosis? __________ | Spectrin |
| Why do you perform cholecystectomy with splenectomy in patients > 5 yo with spherocytosis? | It causes pigmented gallstones |
| Protein mutations in elliptocytosis ___________ | Spectrin and protein 4.1 |
| Definition of Stage I Hodgkin’s lymphoma | 1 area or 2 contiguous areas on the same side of the diaphragm |
| Definition of Stage II Hodgkin’s lymphoma | 2 non-contiguous areas on the same side of the diaphragm |
| Definition of Stage I Hodgkin’s lymphoma | Involved on each side of the diaphragm |
| Definition of Stage I Hodgkin’s lymphoma | Involves any non-lymphoid tissue (other than the spleen) |
| Most common form of Hodgkin’s lymphoma _________ | Nodular sclerosing |
| Treatment for hairy cell leukemia | Splenectomy and interferon-gamma |
| Splenosis is usually related to this event ___________ | Trauma |
| The most common cause of splenic artery or splenic vein thrombosis __________ | Pancreatitis |
| Most common cause of splenic artery aneurysms __________ | Fibromuscular dysplasia or atherosclerosis |
Created by:
StudyBug82
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