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NBDE
Fungi
| Question | Answer |
|---|---|
| blastomycoses | ulcerative skin and bone lesions |
| W-1 glycoprotein surface antigen | blastomycoses |
| chicago disease | blastomycoses |
| cave/spelunker`s disase | histoplasmosis |
| leads to pericarditis amd mediastenal fibrosis | histoplasmosis |
| granulomas and TB-like lesions | histoplasmosis |
| dematiaceous fungi | Chromoblastomysosis |
| cauliflower-like wart lesions | Chromoblastomysosis |
| might be treated with chemotherapy or surgery | Chromoblastomysosis |
| long hyphae with rosetta pattern | Lymphocutaneous Sporotrichosis |
| thick walls, rough macro and rare micro | Microsporum |
| thin walls, smooth marco, many micro | Trichophyton |
| smooth macro, no micro | Epidermophyton |
| tinea capitis Tx | griseofulvum |
| dont normally elicit IM response | Superficial mycoses |
| spaghetti and meatball fungus | Malassezia furfur (-> versicolor) |
| painful ulcers of oral , nasal, GI mucosa | paracoccidiomycosis |
| chiefly affects men | paracoccidiomycosis |
| endemic in S. America | paracoccidiomycosis |
| desert rheumatism | coccidiomycosis |
| fungus spread by dust storms | coccodiomycosis |
| virulence via arthroconidia | coccodiomycosis |
| urease -> alkaline halo | coccodiomycosis |
| clacification of infected lesions | coccodiomycosis |
| C. immitis | coccodiomycosis |
| most prevalent fungal pathogen in the US | cryptococcis |
| found in droppings of pigeons and eucalyptus | cryptococcis |
| only exist in yeast form | cryptococcis |
| contain capsule (unique for fungi) | cryptococcis |
| produce melanin | cryptococcis |
| pneumonia and lung nodules | cryptococcis |
| might lead to meningtis | cryptococcis |
| lung cancer-like lesion | cryptococcis |
| alfatoxin | aspergillosis |
| induce hepatoma | aspergillosis |
| fungus balls = mycetoma | aspergillosis |
| exist only in hyphal state | aspergillosis |
| via BV -> brain | aspergillosis |
| gliotoxin | aspergillosis |
| diabetes, leukopeina | zygomycosis |
| rhinocerebral form -> 85% mortality | zygomycosis |
| most common resp infection in late state HIV | pneumocystis jirveci |
| can transmit from human to human | pneumocystis jirveci |
| not very responsive to anti-fungal Tx | pneumocystis jirveci |
| exist in pulm interstitial tissue (sporocyst) | pneumocystis jirveci |
| ground glass appearance on lung X-ray | pneumocystis jirveci |
| death from asphyxiation | pneumocystis jirveci |
| disrupt heme P-450 | azoles |
| dont absorb from the gut | polyenes |
| requires acidic pH (oral med) | ketoconazole |
| 5-flurocytosine | nucleoside analog |
| drug: enters CSF | 5-flurocytosine |
| drug: interact with tubulin (protein involved in Mit) | griseofulvin |
| drug: interferes with CW synthesis | echinocandins: caspofungin |
| candida reproduction | Asexual budding |
| candida yeast form | blastospore/conidia |
| candida hyphal form | aka mycelial (germ tubes or pseudohyphae) |
| anaerobes | candida |
| tolerates pH from 2 to 9 | candida |
| denture wearers + salivary hypofxn | candida glabrate |
| steroids act as nutrients for | candida |
| localized, painless hyperemia on the palate | chronic erythematous candidiasis |
| perleche | erythematous areas at the corners of mouth |
| perleche | angular chelitis |
| tissue damage by hyphal invasion of heart, SC, urethra | systemic candidiasis |
| candida attachment | fibronectin and laminin on damaged tissue |
| secretes aspartic proteinase and lipase | candida |
| most effective anti-candida IM reponse | PMN`s or CMI |
| high frequency phenotopic switching | candida |
| germ tube formation | candida |
| chlamydospores | candida |
| 2 swish and swallow drugs | Nystatin and clotrimazole |
Created by:
fufik
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