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blastomycoses ulcerative skin and bone lesions
W-1 glycoprotein surface antigen blastomycoses
chicago disease blastomycoses
cave/spelunker`s disase histoplasmosis
leads to pericarditis amd mediastenal fibrosis histoplasmosis
granulomas and TB-like lesions histoplasmosis
dematiaceous fungi Chromoblastomysosis
cauliflower-like wart lesions Chromoblastomysosis
might be treated with chemotherapy or surgery Chromoblastomysosis
long hyphae with rosetta pattern Lymphocutaneous Sporotrichosis
thick walls, rough macro and rare micro Microsporum
thin walls, smooth marco, many micro Trichophyton
smooth macro, no micro Epidermophyton
tinea capitis Tx griseofulvum
dont normally elicit IM response Superficial mycoses
spaghetti and meatball fungus Malassezia furfur (-> versicolor)
painful ulcers of oral , nasal, GI mucosa paracoccidiomycosis
chiefly affects men paracoccidiomycosis
endemic in S. America paracoccidiomycosis
desert rheumatism coccidiomycosis
fungus spread by dust storms coccodiomycosis
virulence via arthroconidia coccodiomycosis
urease -> alkaline halo coccodiomycosis
clacification of infected lesions coccodiomycosis
C. immitis coccodiomycosis
most prevalent fungal pathogen in the US cryptococcis
found in droppings of pigeons and eucalyptus cryptococcis
only exist in yeast form cryptococcis
contain capsule (unique for fungi) cryptococcis
produce melanin cryptococcis
pneumonia and lung nodules cryptococcis
might lead to meningtis cryptococcis
lung cancer-like lesion cryptococcis
alfatoxin aspergillosis
induce hepatoma aspergillosis
fungus balls = mycetoma aspergillosis
exist only in hyphal state aspergillosis
via BV -> brain aspergillosis
gliotoxin aspergillosis
diabetes, leukopeina zygomycosis
rhinocerebral form -> 85% mortality zygomycosis
most common resp infection in late state HIV pneumocystis jirveci
can transmit from human to human pneumocystis jirveci
not very responsive to anti-fungal Tx pneumocystis jirveci
exist in pulm interstitial tissue (sporocyst) pneumocystis jirveci
ground glass appearance on lung X-ray pneumocystis jirveci
death from asphyxiation pneumocystis jirveci
disrupt heme P-450 azoles
dont absorb from the gut polyenes
requires acidic pH (oral med) ketoconazole
5-flurocytosine nucleoside analog
drug: enters CSF 5-flurocytosine
drug: interact with tubulin (protein involved in Mit) griseofulvin
drug: interferes with CW synthesis echinocandins: caspofungin
candida reproduction Asexual budding
candida yeast form blastospore/conidia
candida hyphal form aka mycelial (germ tubes or pseudohyphae)
anaerobes candida
tolerates pH from 2 to 9 candida
denture wearers + salivary hypofxn candida glabrate
steroids act as nutrients for candida
localized, painless hyperemia on the palate chronic erythematous candidiasis
perleche erythematous areas at the corners of mouth
perleche angular chelitis
tissue damage by hyphal invasion of heart, SC, urethra systemic candidiasis
candida attachment fibronectin and laminin on damaged tissue
secretes aspartic proteinase and lipase candida
most effective anti-candida IM reponse PMN`s or CMI
high frequency phenotopic switching candida
germ tube formation candida
chlamydospores candida
2 swish and swallow drugs Nystatin and clotrimazole
Created by: fufik
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