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Pharmacology Final

Question re: Antianginal drugs

Stable Angina is? More frequent pain, that is relieve by drugs
Unstable Angina is? Less pain, not relieved by rest, may even occur during rest
The function of Organic Nitrates is? they dilate the large myocardial arteries to increase the blood supply of the heart
Common side effects of Orgnic Nitrates are? Headache and postural hypotension
Six hours is needed between taking this drug ______ and Organic Nitrates to avoid interaction that can cause dangerous hypotension? Sildenafil (Viagra)
This drug giving sublingually is useful in treating all forms of angina? Nitroglycerine
This drug is used for the prevention of angina, not for acute attacks? Isosoribide dinitrate/ Isosorbide mononitrate
The action of B-Blockers when treating the heart is? They decrease the oxygen demands of the myoardium by lowering both the rate and the force of contraction of the heart
Patients with what diseases are B-Blockers contraindicated? Asthma, diabetes, severe bradycardia, peripherial vascular diease, or COPD
How does drugs like Diltiazem, Amlodipine, Averapamil work to trea angina? They block calcium influx into the smooth muscle cells of the arteries causing them to dilate
This cannel calcium blocker drug is no longer used as a single agent because it's toxicity causes myocardial infarctions? Nifedipine
Baby aspirin is a widely used drug to reduce the risk of myocardial infarction, what is th mechanism of action of aspirin? Inhibition of thromboxane a2 snthesis in the platelets
Which drug is recommended for loweing blood cholesterol inhibits the synthesis of cholesterol by blocking HMG-CoA reductase? Rosuvastatin
Which is the drug of choice for relieving acute coronary spasm? Nitrogylcerine
What is the mechanism of action of streptokinase when treating MI's? Activation of plasminogen to plasma
The drug used to treat anemia in end renal failure is? Erythropoietin
What is the major side effect of all the anticoagulants? Hemorrhage
What is the mechanism of action of Heparin? binding of antithrombin III and subsequent rapid inactivation of thrombin and Xa
the drug of choice for treatment of paroxysmal supraventricular tachycardia is? Adenosine
Which drug is used to control ventricular rate in artial fibrllatin or flutter? Digoxin
which drug inhibits gastrointestinal absorption of cholesterol? Ezetimibe
This drug interfares with synthesis of vitamin K-dependent clotting factors? Warfarin
Which drug inhibits plasminogen activation thereby stopping bleeding? Aminocaproic acid
This drug is used to treat hypertension in pregnant women? Methyldopa
Used to treat heparin induced hemorrhage? Protamine
The side effects of Niacin include? flushing and pruritus
What is the mechanism of action of Clopidegrol? block platelet aggregation by inhibting platelet ADP receptor
The first line of drug therapy for hypertension is? Diuretics
ACE inhibitors and b-Blockers is not effective in which group of patients? African American
Because they do not affect glucose level which type of antihypertension drugs are to treat patients with diabetes? ACE inhibitors
What is the mechanism of action for a-Blocker when treating hypertension? They produce a competitive block of a1 adrerenoceptors, They dilate both arteries and viens which causes a decrease in peripheral vascular resistance and lower the BP, however side effect can be postural hypotension
Prazosin, Doxazosin, Terazosin are which class of drugs? a-Blockers
This drug is posionous when giving orally because is hydrolysis to cyanide? Sodium Nitroprusside
What dopamine agonist is used to treat acute hypertensive emergencies? Fenoldopam
What is the mechanism of the antiplalet drug Diprydamole? Inhibits phosphodiaaterase, increasing cAMP levels in platelets to promote PGI2, increasing the levels of adenosine, a coronary vasodilator
This thrombolytic drug activate plasminogen to plasmin? Streptokinase
This drug inhibits plasminogen activation to treat bleeding? Aminocaproic acid
Used to treat end stage renal failure ________ synthesized in the kidney in response to hypoxia or anemia? Erthropoietin
Is used to treat megaloblatic anemia? Cyanocobalamin (Vitamin B12) or Folic acid
This is the first choice for treament of patients with hypercholestoralemia , there structural analogue is a precusor of cholesterol? HMG-CoA reductase inhibitors
What are the most potent HMG-CoA reductase inhibitors? Atrovastatin and Rosuvastatin
What is the adverse effects of HMG-CoA reductase inhibitors? LV function abnormalities, myopathy, rhabdomyolysis
What type of drugs causes the LV to use cholesterol to make more bile acids by binding to bile acids in the small intestines and prevent their reabsorption? Bile acid sequestrants
What is the mechanism of Furosemide? They inhibit chloride reabsorption in the ascending loop of Henle
Which loop diuretic is the most ototoxic? Ethacrynic acid
What is the mechanism of Potassium sparing diuretics? they enhance sodium excretion and retain potassium inthe distal tubule
What is the undiserable effect of Spironolactone? Hyperkalemia
This drug may preserve renal blood flow and is used in patient with impaired renal function? Dopamine
This drug increases the contractility of the heart without chaning Bp or heart rate? Dobutamine
What is the mechanism of ClassI antiarrhythmic drugs? They block sodium entry into the cell during depolarization
This Class 1a antiarrythmic drug is useful in the tx of atrial and venticular arrhytmias? Procainamide
This Class 1b drug is used for the treatment of ventricular arrhythmias? Lidocaine
What is the drug of choice for the tx of Paroxysmal supraventricular tachycardia? Adenosine
Created by: mswilsonlmt